Monkeypox outbreak in Madrid (Spain) : Clinical and virological aspects

Copyright © 2022 The British Infection Association. Published by Elsevier Ltd. All rights reserved..

BACKGROUND: Monkeypox is the most prevalent Orthopoxvirus zoonosis infection since the eradication of smallpox. The current multi-country outbreak involves five WHO regions affecting mainly Europe. Accurate clinical and virological aspects of the disease outside endemic areas are needed.

METHODS: We performed an observational study of cases diagnosed in Madrid (Spain) (May/June 2022). Confirmation from vesicular lesions swabs, Orthopoxvirus real-time PCR, sequencing, phylogenetic analysis, and direct detection by Electron microscopy was performed. In addition, a structured epidemiological questionnaire was completed systematically to gather sociodemographic, clinical, and behavioral data from all confirmed cases.

FINDINGS: We extracted data from 48 patients, all cisgender men. The median age was 35 years (IQR 29 - 44), and 87.5% were MSM. The most prevalent symptoms were the presence of vesicular-umbilicated and pseudo-pustular skin lesions (93.8%), asthenia (66.6%), and fever (52.1%). In addition, the location of the lesions in the genital or perianal area was related to the role in sexual intercourse (p<0.001). Sequencing analysis indicated the virus circulating in Spain belongs to the western African clade. Like the other European cases in the outbreak, the Spanish isolates are a direct descendant of viruses previously detected in Nigeria, the UK, Singapore, and Israel in 2017-2018.

CONCLUSIONS: Monkeypox is an emerging infectious disease in Europe where community transmission is reported, mainly in MSM. The first symptom was skin lesions instead of classical fever and rash. The disease follows a self-limited course, and there have been no cases with a serious presentation or severe complications.

Errataetall:

CommentIn: J Infect. 2022 Nov;85(5):e145-e148. - PMID 35963550

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:85

Enthalten in:

The Journal of infection - 85(2022), 4 vom: 05. Okt., Seite 412-417

Sprache:

Englisch

Beteiligte Personen:

Orviz, Eva [VerfasserIn]
Negredo, Anabel [VerfasserIn]
Ayerdi, Oskar [VerfasserIn]
Vázquez, Ana [VerfasserIn]
Muñoz-Gomez, Ana [VerfasserIn]
Monzón, Sara [VerfasserIn]
Clavo, Petunia [VerfasserIn]
Zaballos, Angel [VerfasserIn]
Vera, Mar [VerfasserIn]
Sánchez, Patricia [VerfasserIn]
Cabello, Noemi [VerfasserIn]
Jiménez, Pilar [VerfasserIn]
Pérez-García, Jorge A [VerfasserIn]
Varona, Sarai [VerfasserIn]
Del Romero, Jorge [VerfasserIn]
Cuesta, Isabel [VerfasserIn]
Delgado-Iribarren, Alberto [VerfasserIn]
Torres, Montse [VerfasserIn]
Sagastagoitia, Iñigo [VerfasserIn]
Palacios, Gustavo [VerfasserIn]
Estrada, Vicente [VerfasserIn]
Sánchez-Seco, Maria Paz [VerfasserIn]
Grupo Viruela del Simio Madrid CNM/ISCIII/HCSC/Sandoval [VerfasserIn]
Ballesteros, Juan [Sonstige Person]
Baza, Begoña [Sonstige Person]
Carrió, Juan Carlos [Sonstige Person]
Chocron, Cynthia [Sonstige Person]
Fedele, Giovanni [Sonstige Person]
García-Amil, Cristina [Sonstige Person]
Herrero, Laura [Sonstige Person]
Homen, Reynaldo [Sonstige Person]
Mariano, Alberto [Sonstige Person]
Martínez-Burgoa, Teresa [Sonstige Person]
Molero, Francisca [Sonstige Person]
Navarro, Maria Luisa [Sonstige Person]
Núñez, Maria José [Sonstige Person]
Perez-Somarriba, Juncal [Sonstige Person]
Puerta, Teresa [Sonstige Person]
Rodríguez-Añover, Javier [Sonstige Person]
Pastrana, Esperanza Pérez [Sonstige Person]
Jiménez, Mercedes [Sonstige Person]
de la Vega, Leticia [Sonstige Person]
Vergas, Jorge [Sonstige Person]
Zarza, Isabel [Sonstige Person]

Links:

Volltext

Themen:

Communicable diseases
Emerging
Journal Article
Monkeypox
Observational Study
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 13.09.2022

Date Revised 13.12.2023

published: Print-Electronic

CommentIn: J Infect. 2022 Nov;85(5):e145-e148. - PMID 35963550

Citation Status MEDLINE

doi:

10.1016/j.jinf.2022.07.005

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM343512343