Analysis of viral nucleic acids in duodenal biopsies from adult patients with celiac disease
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved..
OBJECTIVE: The purpose of this study was to investigate the presence of Adenovirus, Epstein-Barr virus (EBV), HHV-6 and cytomegalovirus (CMV) nucleic acids in the gastrointestinal biopsies from active CD patients.
METHODS: Gastrointestinal biopsies of 40 active CD patients and 40 non-CD patients were collected during the endoscopic investigation of gastrointestinal symptoms.
RESULTS: HHV-6B was found in 62.5% of CD patients and in 65% of non-CD individuals, whereas the prevalence of EBV-positive samples was 20 and 10%, respectively. Nucleic acids from HHV-6A, CMV and adenovirus were not detected in any group.
CONCLUSION: These data suggest that these viruses may not play a role in the pathogenesis of acute CD, but they do not exclude the possibility that viruses can act as a trigger for the onset of celiac disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
European journal of gastroenterology & hepatology - 34(2022), 11 vom: 01. Nov., Seite 1107-1110 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Calabretto, Marianna [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 30.09.2022 Date Revised 16.11.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1097/MEG.0000000000002404 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM343507161 |
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| 245 | 1 | 0 | |a Analysis of viral nucleic acids in duodenal biopsies from adult patients with celiac disease |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 30.09.2022 | ||
| 500 | |a Date Revised 16.11.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: The purpose of this study was to investigate the presence of Adenovirus, Epstein-Barr virus (EBV), HHV-6 and cytomegalovirus (CMV) nucleic acids in the gastrointestinal biopsies from active CD patients | ||
| 520 | |a METHODS: Gastrointestinal biopsies of 40 active CD patients and 40 non-CD patients were collected during the endoscopic investigation of gastrointestinal symptoms | ||
| 520 | |a RESULTS: HHV-6B was found in 62.5% of CD patients and in 65% of non-CD individuals, whereas the prevalence of EBV-positive samples was 20 and 10%, respectively. Nucleic acids from HHV-6A, CMV and adenovirus were not detected in any group | ||
| 520 | |a CONCLUSION: These data suggest that these viruses may not play a role in the pathogenesis of acute CD, but they do not exclude the possibility that viruses can act as a trigger for the onset of celiac disease | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Nucleic Acids |2 NLM | |
| 700 | 1 | |a Di Carlo, Daniele |e verfasserin |4 aut | |
| 700 | 1 | |a Falasca, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzuti, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Meacci, Arianna |e verfasserin |4 aut | |
| 700 | 1 | |a Donato, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Greco, Nicoletta |e verfasserin |4 aut | |
| 700 | 1 | |a Mezzatesta, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Morrone, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Turriziani, Ombretta |e verfasserin |4 aut | |
| 700 | 1 | |a Picarelli, Antonio |e verfasserin |4 aut | |
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