Frequent productive cough : Symptom burden and future exacerbation risk among patients with asthma and/or COPD in the NOVELTY study
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved..
INTRODUCTION: Persistent cough with sputum production is an important clinical trait in chronic obstructive pulmonary disease (COPD). We defined "frequent productive cough" based on 2 questions from the St George's Respiratory Questionnaire (SGRQ) and sought to determine its occurrence and associated outcomes in patients with physician-assigned asthma and/or COPD from the NOVELTY study.
METHODS: Frequent productive cough was defined as cough and sputum production most or several days/week for the past 3 months (scoring ≥3 for both SGRQ questions). Relationships with baseline disease characteristics and exacerbations over 12 months' follow-up were examined using logistic regression.
RESULTS: Baseline SGRQ data were available for 7125 patients, of whom 31.3% had frequent productive cough. It was more common in asthma+COPD (38.8%) and COPD (38.1%) than asthma (25.0%), increasing with physician-assessed severity, and in current versus former and never smokers. Patient-reported symptomatic worsening was more common in patients with versus without frequent productive cough. Reduced post-bronchodilator FEV1 (odds ratio [OR] per 10% decrement 1.14 [95% confidence interval 1.11-1.16]) and history of pollutant exposure at home/work (OR 1.50 [1.33-1.69]) were associated with frequent productive cough in all diagnoses. Patients with baseline frequent productive cough were more likely to have ≥1 exacerbation over the subsequent 12 months (OR 1.71 [1.52-1.93]), including exacerbations requiring hospital admission and those treated with oral corticosteroids.
CONCLUSIONS: Frequent productive cough represents an important indicator of adverse clinical outcomes across asthma and/or COPD. Research into the underlying pathologic mechanisms is required to support targeted therapy development.
CLINICALTRIALS: GOV: NCT02760329.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:200 |
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| Enthalten in: |
Respiratory medicine - 200(2022) vom: 16. Aug., Seite 106921 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hughes, Rod [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.09.2022 Date Revised 28.10.2022 published: Print-Electronic ClinicalTrials.gov: NCT02760329 Citation Status MEDLINE |
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| doi: |
10.1016/j.rmed.2022.106921 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM343406098 |
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| 500 | |a Date Completed 13.09.2022 | ||
| 500 | |a Date Revised 28.10.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT02760329 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a INTRODUCTION: Persistent cough with sputum production is an important clinical trait in chronic obstructive pulmonary disease (COPD). We defined "frequent productive cough" based on 2 questions from the St George's Respiratory Questionnaire (SGRQ) and sought to determine its occurrence and associated outcomes in patients with physician-assigned asthma and/or COPD from the NOVELTY study | ||
| 520 | |a METHODS: Frequent productive cough was defined as cough and sputum production most or several days/week for the past 3 months (scoring ≥3 for both SGRQ questions). Relationships with baseline disease characteristics and exacerbations over 12 months' follow-up were examined using logistic regression | ||
| 520 | |a RESULTS: Baseline SGRQ data were available for 7125 patients, of whom 31.3% had frequent productive cough. It was more common in asthma+COPD (38.8%) and COPD (38.1%) than asthma (25.0%), increasing with physician-assessed severity, and in current versus former and never smokers. Patient-reported symptomatic worsening was more common in patients with versus without frequent productive cough. Reduced post-bronchodilator FEV1 (odds ratio [OR] per 10% decrement 1.14 [95% confidence interval 1.11-1.16]) and history of pollutant exposure at home/work (OR 1.50 [1.33-1.69]) were associated with frequent productive cough in all diagnoses. Patients with baseline frequent productive cough were more likely to have ≥1 exacerbation over the subsequent 12 months (OR 1.71 [1.52-1.93]), including exacerbations requiring hospital admission and those treated with oral corticosteroids | ||
| 520 | |a CONCLUSIONS: Frequent productive cough represents an important indicator of adverse clinical outcomes across asthma and/or COPD. Research into the underlying pathologic mechanisms is required to support targeted therapy development | ||
| 520 | |a CLINICALTRIALS: GOV: NCT02760329 | ||
| 650 | 4 | |a Clinical Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Chronic bronchitis | |
| 650 | 4 | |a Chronic mucus hypersecretion | |
| 650 | 4 | |a Frequent productive cough | |
| 650 | 4 | |a Obstructive lung diseases | |
| 650 | 4 | |a Patient-reported outcome measures | |
| 650 | 4 | |a Sputum | |
| 650 | 7 | |a Adrenal Cortex Hormones |2 NLM | |
| 700 | 1 | |a Rapsomaniki, Eleni |e verfasserin |4 aut | |
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| 700 | 1 | |a Keen, Christina |e verfasserin |4 aut | |
| 700 | 1 | |a Make, Barry J |e verfasserin |4 aut | |
| 700 | 1 | |a Burgel, Pierre-Régis |e verfasserin |4 aut | |
| 700 | 1 | |a Tomaszewski, Erin L |e verfasserin |4 aut | |
| 700 | 1 | |a Müllerová, Hana |e verfasserin |4 aut | |
| 700 | 1 | |a Reddel, Helen K |e verfasserin |4 aut | |
| 700 | 0 | |a NOVELTY study investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Benhabib, Gabriel |e investigator |4 oth | |
| 700 | 1 | |a Ruiz, Xavier Bocca |e investigator |4 oth | |
| 700 | 1 | |a Olmo, Ricardo Del |e investigator |4 oth | |
| 700 | 1 | |a Lisanti, Raul Eduardo |e investigator |4 oth | |
| 700 | 1 | |a Marino, Gustavo |e investigator |4 oth | |
| 700 | 1 | |a Mattarucco, Walter |e investigator |4 oth | |
| 700 | 1 | |a Nogueira, Juan |e investigator |4 oth | |
| 700 | 1 | |a Parody, Maria |e investigator |4 oth | |
| 700 | 1 | |a Pascale, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Rodriguez, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Silva, Damian |e investigator |4 oth | |
| 700 | 1 | |a Svetliza, Graciela |e investigator |4 oth | |
| 700 | 1 | |a Victorio, Carlos F |e investigator |4 oth | |
| 700 | 1 | |a Rolon, Roxana Willigs |e investigator |4 oth | |
| 700 | 1 | |a Yañez, Anahi |e investigator |4 oth | |
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