Subepicardial burn injuries in bullfrog heart induce electrocardiogram changes mimicking inferior wall myocardial infarction
Using bullfrog hearts, we previously reproduced a ST segment elevation in electrocardiogram (ECG), mimicking human ischemic heart disease. In the present study, by inducing subepicardial burn injuries on the inferior part of the frog heart ventricle, we could reproduce typical ECG changes observed in human inferior wall myocardial infarction, such as the marked elevation of the ST segments in inferior limb leads (II, III, aVF) and their reciprocal depression in the opposite limb leads (I, aVL). Due to the decrease in Na+/K+-ATPase protein expression, the resting membrane potential of injured cardiomyocytes shifted toward depolarization. Such induced electrical difference between the injured and intact cardiomyocytes was thought to be responsible for the creation of "currents of injury" and the subsequent ST segment changes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:84 |
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| Enthalten in: |
The Journal of veterinary medical science - 84(2022), 9 vom: 01. Sept., Seite 1205-1210 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kazama, Itsuro [VerfasserIn] |
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| Links: |
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| Themen: |
Bullfrog heart |
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| Anmerkungen: |
Date Completed 08.09.2022 Date Revised 12.10.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1292/jvms.22-0243 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM343316102 |
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| 245 | 1 | 0 | |a Subepicardial burn injuries in bullfrog heart induce electrocardiogram changes mimicking inferior wall myocardial infarction |
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| 500 | |a Date Revised 12.10.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Using bullfrog hearts, we previously reproduced a ST segment elevation in electrocardiogram (ECG), mimicking human ischemic heart disease. In the present study, by inducing subepicardial burn injuries on the inferior part of the frog heart ventricle, we could reproduce typical ECG changes observed in human inferior wall myocardial infarction, such as the marked elevation of the ST segments in inferior limb leads (II, III, aVF) and their reciprocal depression in the opposite limb leads (I, aVL). Due to the decrease in Na+/K+-ATPase protein expression, the resting membrane potential of injured cardiomyocytes shifted toward depolarization. Such induced electrical difference between the injured and intact cardiomyocytes was thought to be responsible for the creation of "currents of injury" and the subsequent ST segment changes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Na+/K+-ATPase expression | |
| 650 | 4 | |a bullfrog heart | |
| 650 | 4 | |a inferior wall myocardial infarction | |
| 650 | 4 | |a reciprocal ST segment depression | |
| 700 | 1 | |a Kuwana, Ryo |e verfasserin |4 aut | |
| 700 | 1 | |a Muto, Mizuki |e verfasserin |4 aut | |
| 700 | 1 | |a Nagano, Amu |e verfasserin |4 aut | |
| 700 | 1 | |a Fujimura, Ririka |e verfasserin |4 aut | |
| 700 | 1 | |a Asada, Ayano |e verfasserin |4 aut | |
| 700 | 1 | |a Tamada, Tsutomu |e verfasserin |4 aut | |
| 700 | 1 | |a Shimoyama, Makoto |e verfasserin |4 aut | |
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