Air pollution and green spaces in relation to breast cancer risk among pre and postmenopausal women : A mega cohort from Catalonia
Copyright © 2022 Elsevier Inc. All rights reserved..
BACKGROUND: The association between air pollution and green spaces with breast cancer risk stratified by menopausal status has not been frequently investigated despite its importance given the different impact of risk factors on breast cancer risk depending on menopausal status.
OBJECTIVES: To study the association between air pollution, green spaces and pre and postmenopausal breast cancer risk.
METHODS: We conducted a population-based cohort study using electronic primary care records in Catalonia. We included women aged 17-85 years free of cancer at study entry between 2009 and 2017. Our exposures were particulate matter <2.5 μm (PM2.5) & <10 μm (PM10), nitrogen dioxide (NO2), normalized difference vegetation index (NDVI), and percentage of green spaces estimated at the census tract level. Breast cancer was identified with ICD-10 code C50. We estimated cause-specific hazard ratios (HR) for the relationship between each individual exposure and pre and postmenopausal breast cancer risk, using linear and non-linear models.
RESULTS: Of the 1,054,180 pre and 744,658 postmenopausal women followed for a median of 10 years, 6,126 and 17,858 developed breast cancer, respectively. Among premenopausal women, only very high levels of PM10 (≥46 μg/m3) were associated with increased cancer risk (compared to lower levels) in non-linear models. Among postmenopausal women, an interquartile range increase in PM2.5 (HR:1.03; 95%CI:1.01-1.04), PM10 (1.03; 1.01-1.05), and NO2 (1.05; 1.02-1.08) were associated with higher cancer risk. NDVI was negatively associated with decreased cancer risk only among postmenopausal women who did not change residence during follow-up (0.84; 0.71-0.99) or who were followed for at least three years (0.82; 0.69-0.98).
DISCUSSION: Living in areas with high concentrations of PM2.5, PM10, and NO2 increases breast cancer risk in postmenopausal women while long-term exposure to green spaces may decrease this risk. Only very high concentrations of PM10 increase breast cancer risk in premenopausal women.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:214 |
|---|---|
| Enthalten in: |
Environmental research - 214(2022), Pt 1 vom: 01. Nov., Seite 113838 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Terre-Torras, Isaura [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Air Pollutants |
|---|
| Anmerkungen: |
Date Completed 30.08.2022 Date Revised 29.09.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.envres.2022.113838 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM343312859 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM343312859 | ||
| 003 | DE-627 | ||
| 005 | 20231226020144.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.envres.2022.113838 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1144.xml |
| 035 | |a (DE-627)NLM343312859 | ||
| 035 | |a (NLM)35810806 | ||
| 035 | |a (PII)S0013-9351(22)01165-3 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Terre-Torras, Isaura |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Air pollution and green spaces in relation to breast cancer risk among pre and postmenopausal women |b A mega cohort from Catalonia |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.08.2022 | ||
| 500 | |a Date Revised 29.09.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: The association between air pollution and green spaces with breast cancer risk stratified by menopausal status has not been frequently investigated despite its importance given the different impact of risk factors on breast cancer risk depending on menopausal status | ||
| 520 | |a OBJECTIVES: To study the association between air pollution, green spaces and pre and postmenopausal breast cancer risk | ||
| 520 | |a METHODS: We conducted a population-based cohort study using electronic primary care records in Catalonia. We included women aged 17-85 years free of cancer at study entry between 2009 and 2017. Our exposures were particulate matter <2.5 μm (PM2.5) & <10 μm (PM10), nitrogen dioxide (NO2), normalized difference vegetation index (NDVI), and percentage of green spaces estimated at the census tract level. Breast cancer was identified with ICD-10 code C50. We estimated cause-specific hazard ratios (HR) for the relationship between each individual exposure and pre and postmenopausal breast cancer risk, using linear and non-linear models | ||
| 520 | |a RESULTS: Of the 1,054,180 pre and 744,658 postmenopausal women followed for a median of 10 years, 6,126 and 17,858 developed breast cancer, respectively. Among premenopausal women, only very high levels of PM10 (≥46 μg/m3) were associated with increased cancer risk (compared to lower levels) in non-linear models. Among postmenopausal women, an interquartile range increase in PM2.5 (HR:1.03; 95%CI:1.01-1.04), PM10 (1.03; 1.01-1.05), and NO2 (1.05; 1.02-1.08) were associated with higher cancer risk. NDVI was negatively associated with decreased cancer risk only among postmenopausal women who did not change residence during follow-up (0.84; 0.71-0.99) or who were followed for at least three years (0.82; 0.69-0.98) | ||
| 520 | |a DISCUSSION: Living in areas with high concentrations of PM2.5, PM10, and NO2 increases breast cancer risk in postmenopausal women while long-term exposure to green spaces may decrease this risk. Only very high concentrations of PM10 increase breast cancer risk in premenopausal women | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Air pollution | |
| 650 | 4 | |a Breast cancer | |
| 650 | 4 | |a Green spaces | |
| 650 | 4 | |a Malignant neoplasm | |
| 650 | 4 | |a Urban environment | |
| 650 | 7 | |a Air Pollutants |2 NLM | |
| 650 | 7 | |a Particulate Matter |2 NLM | |
| 650 | 7 | |a Nitrogen Dioxide |2 NLM | |
| 650 | 7 | |a S7G510RUBH |2 NLM | |
| 700 | 1 | |a Recalde, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Díaz, Yesika |e verfasserin |4 aut | |
| 700 | 1 | |a de Bont, Jeroen |e verfasserin |4 aut | |
| 700 | 1 | |a Bennett, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Aragón, María |e verfasserin |4 aut | |
| 700 | 1 | |a Cirach, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a O'Callaghan-Gordo, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Nieuwenhuijsen, Mark J |e verfasserin |4 aut | |
| 700 | 1 | |a Duarte-Salles, Talita |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Environmental research |d 1967 |g 214(2022), Pt 1 vom: 01. Nov., Seite 113838 |w (DE-627)NLM000029521 |x 1096-0953 |7 nnns |
| 773 | 1 | 8 | |g volume:214 |g year:2022 |g number:Pt 1 |g day:01 |g month:11 |g pages:113838 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.envres.2022.113838 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 214 |j 2022 |e Pt 1 |b 01 |c 11 |h 113838 | ||