SARS-CoV-2 infection risk among 77,587 healthcare workers : a national observational longitudinal cohort study in Wales, United Kingdom, April to November 2020
OBJECTIVES: To better understand the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among healthcare workers, leading to recommendations for the prioritisation of personal protective equipment, testing, training and vaccination.
DESIGN: Observational, longitudinal, national cohort study.
SETTING: Our cohort were secondary care (hospital-based) healthcare workers employed by NHS Wales (United Kingdom) organisations from 1 April 2020 to 30 November 2020.
PARTICIPANTS: We included 577,756 monthly observations among 77,587 healthcare workers. Using linked anonymised datasets, participants were grouped into 20 staff roles. Additionally, each role was deemed either patient-facing, non-patient-facing or undetermined. This was linked to individual demographic details and dates of positive SARS-CoV-2 PCR tests.
MAIN OUTCOME MEASURES: We used univariable and multivariable logistic regression models to determine odds ratios (ORs) for the risk of a positive SARS-CoV-2 PCR test.
RESULTS: Patient-facing healthcare workers were at the highest risk of SARS-CoV-2 infection with an adjusted OR (95% confidence interval [CI]) of 2.28 (95% CI 2.10-2.47). We found that after adjustment, foundation year doctors (OR 1.83 [95% CI 1.47-2.27]), healthcare support workers [OR 1.36 [95% CI 1.20-1.54]) and hospital nurses (OR 1.27 [95% CI 1.12-1.44]) were at the highest risk of infection among all staff groups. Younger healthcare workers and those living in more deprived areas were at a higher risk of infection. We also observed that infection rates varied over time and by organisation.
CONCLUSIONS: These findings have important policy implications for the prioritisation of vaccination, testing, training and personal protective equipment provision for patient-facing roles and the higher risk staff groups.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:115 |
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| Enthalten in: |
Journal of the Royal Society of Medicine - 115(2022), 12 vom: 05. Dez., Seite 467-478 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hollinghurst, Joe [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 15.12.2022 Date Revised 06.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/01410768221107119 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM343167840 |
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| 100 | 1 | |a Hollinghurst, Joe |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a SARS-CoV-2 infection risk among 77,587 healthcare workers |b a national observational longitudinal cohort study in Wales, United Kingdom, April to November 2020 |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 06.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To better understand the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among healthcare workers, leading to recommendations for the prioritisation of personal protective equipment, testing, training and vaccination | ||
| 520 | |a DESIGN: Observational, longitudinal, national cohort study | ||
| 520 | |a SETTING: Our cohort were secondary care (hospital-based) healthcare workers employed by NHS Wales (United Kingdom) organisations from 1 April 2020 to 30 November 2020 | ||
| 520 | |a PARTICIPANTS: We included 577,756 monthly observations among 77,587 healthcare workers. Using linked anonymised datasets, participants were grouped into 20 staff roles. Additionally, each role was deemed either patient-facing, non-patient-facing or undetermined. This was linked to individual demographic details and dates of positive SARS-CoV-2 PCR tests | ||
| 520 | |a MAIN OUTCOME MEASURES: We used univariable and multivariable logistic regression models to determine odds ratios (ORs) for the risk of a positive SARS-CoV-2 PCR test | ||
| 520 | |a RESULTS: Patient-facing healthcare workers were at the highest risk of SARS-CoV-2 infection with an adjusted OR (95% confidence interval [CI]) of 2.28 (95% CI 2.10-2.47). We found that after adjustment, foundation year doctors (OR 1.83 [95% CI 1.47-2.27]), healthcare support workers [OR 1.36 [95% CI 1.20-1.54]) and hospital nurses (OR 1.27 [95% CI 1.12-1.44]) were at the highest risk of infection among all staff groups. Younger healthcare workers and those living in more deprived areas were at a higher risk of infection. We also observed that infection rates varied over time and by organisation | ||
| 520 | |a CONCLUSIONS: These findings have important policy implications for the prioritisation of vaccination, testing, training and personal protective equipment provision for patient-facing roles and the higher risk staff groups | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a healthcare workers | |
| 650 | 4 | |a infection risk | |
| 650 | 4 | |a public health | |
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| 700 | 1 | |a Szakmany, Tamas |e verfasserin |4 aut | |
| 700 | 1 | |a Pugh, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Davies, Gwyneth A |e verfasserin |4 aut | |
| 700 | 1 | |a Sivakumaran, Shanya |e verfasserin |4 aut | |
| 700 | 1 | |a Jarvis, Rebecca |e verfasserin |4 aut | |
| 700 | 1 | |a Rolles, Martin |e verfasserin |4 aut | |
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| 700 | 1 | |a Akbari, Ashley |e verfasserin |4 aut | |
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| 700 | 1 | |a Gravenor, Mike B |e verfasserin |4 aut | |
| 700 | 1 | |a Lyons, Ronan A |e verfasserin |4 aut | |
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