Real-world treatment patterns for patients with newly diagnosed multiple myeloma in Alberta, Canada
The purpose of this study is to describe the real-world multiple myeloma (MM) population in Alberta by examining patient/clinical characteristics and the treatment landscape. A retrospective, observational study was conducted using province-wide, administrative health data from Alberta, Canada evaluating newly diagnosed MM (NDMM) patients. Between 1 April 2011 and 31 March 2017, 1377 treated NDMM cases were identified. Of those, 328 (23.8%) received an autologous stem cell transplant (ASCT) within the first year of diagnosis. In the ASCT group, 189 advanced to second-line (57.6%), 103 (32.6%) to third-line and 97 (29.5%) had four or more lines of therapy. In non-ASCT patients, 553 (52.7%) advanced to second-line, 238 (22.7%) to third-line, and 154 (14.7%) had 4 or more lines of therapy. We observed a significant treatment attrition rate in NDMM. Therefore, the use of best therapy upfront and novel strategies aiming to decrease attrition rates in MM is encouraged.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
---|---|
Enthalten in: |
Leukemia & lymphoma - 63(2022), 11 vom: 05. Nov., Seite 2557-2564 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Jimenez-Zepeda, Victor H [VerfasserIn] |
---|
Links: |
---|
Themen: |
Epidemiology |
---|
Anmerkungen: |
Date Completed 11.11.2022 Date Revised 21.11.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1080/10428194.2022.2092852 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM343140276 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM343140276 | ||
003 | DE-627 | ||
005 | 20231226015733.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1080/10428194.2022.2092852 |2 doi | |
028 | 5 | 2 | |a pubmed24n1143.xml |
035 | |a (DE-627)NLM343140276 | ||
035 | |a (NLM)35793400 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Jimenez-Zepeda, Victor H |e verfasserin |4 aut | |
245 | 1 | 0 | |a Real-world treatment patterns for patients with newly diagnosed multiple myeloma in Alberta, Canada |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 11.11.2022 | ||
500 | |a Date Revised 21.11.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a The purpose of this study is to describe the real-world multiple myeloma (MM) population in Alberta by examining patient/clinical characteristics and the treatment landscape. A retrospective, observational study was conducted using province-wide, administrative health data from Alberta, Canada evaluating newly diagnosed MM (NDMM) patients. Between 1 April 2011 and 31 March 2017, 1377 treated NDMM cases were identified. Of those, 328 (23.8%) received an autologous stem cell transplant (ASCT) within the first year of diagnosis. In the ASCT group, 189 advanced to second-line (57.6%), 103 (32.6%) to third-line and 97 (29.5%) had four or more lines of therapy. In non-ASCT patients, 553 (52.7%) advanced to second-line, 238 (22.7%) to third-line, and 154 (14.7%) had 4 or more lines of therapy. We observed a significant treatment attrition rate in NDMM. Therefore, the use of best therapy upfront and novel strategies aiming to decrease attrition rates in MM is encouraged | ||
650 | 4 | |a Observational Study | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Multiple myeloma | |
650 | 4 | |a epidemiology | |
650 | 4 | |a lines of therapy | |
650 | 4 | |a real-world data | |
700 | 1 | |a Chen, Guanmin |e verfasserin |4 aut | |
700 | 1 | |a Shaw, Eileen |e verfasserin |4 aut | |
700 | 1 | |a Farris, Megan S |e verfasserin |4 aut | |
700 | 1 | |a Cowling, Tara |e verfasserin |4 aut | |
700 | 1 | |a Tay, Jason |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Leukemia & lymphoma |d 1989 |g 63(2022), 11 vom: 05. Nov., Seite 2557-2564 |w (DE-627)NLM012624047 |x 1029-2403 |7 nnns |
773 | 1 | 8 | |g volume:63 |g year:2022 |g number:11 |g day:05 |g month:11 |g pages:2557-2564 |
856 | 4 | 0 | |u http://dx.doi.org/10.1080/10428194.2022.2092852 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 63 |j 2022 |e 11 |b 05 |c 11 |h 2557-2564 |