Thromboembolic Disease in Patients With Cancer and COVID-19 : Risk Factors, Prevention and Practical Thromboprophylaxis Recommendations-State-of-the-Art
Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved..
Cancer and COVID-19 are both well-established risk factors predisposing to thrombosis. Both disease entities are correlated with increased incidence of venous thrombotic events through multifaceted pathogenic mechanisms involving the interaction of cancer cells or SARS-CoV2 on the one hand and the coagulation system and endothelial cells on the other hand. Thromboprophylaxis is recommended for hospitalized patients with active cancer and high-risk outpatients with cancer receiving anticancer treatment. Universal thromboprophylaxis with a high prophylactic dose of low molecular weight heparins (LMWH) or therapeutic dose in select patients, is currentlyindicated for hospitalized patients with COVID-19. Also, prophylactic anticoagulation is recommended for outpatients with COVID-19 at high risk for thrombosis or disease worsening. However, whether there is an additive risk of thrombosis when a patient with cancer is infected with SARS-CoV2 remains unclear In the current review, we summarize and critically discuss the literature regarding the epidemiology of thrombotic events in patients with cancer and concomitant COVID-19, the thrombotic risk assessment, and the recommendations on thromboprophylaxis for this subgroup of patients. Current data do not support an additive thrombotic risk for patients with cancer and COVID-19. Of note, patients with cancer have less access to intensive care unit care, a setting associated with high thrombotic risk. Based on current evidence, patients with cancer and COVID-19 should be assessed with well-established risk assessment models for medically ill patients and receive thromboprophylaxis, preferentially with LMWH, according to existing recommendations. Prospective trials on well-characterized populations do not exist.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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Enthalten in: |
Anticancer research - 42(2022), 7 vom: 26. Juli, Seite 3261-3274 |
Sprache: |
Englisch |
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Links: |
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Themen: |
Anticoagulants |
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Anmerkungen: |
Date Completed 06.07.2022 Date Revised 08.07.2022 published: Print Citation Status MEDLINE |
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doi: |
10.21873/anticanres.15815 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM343109190 |
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520 | |a Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. | ||
520 | |a Cancer and COVID-19 are both well-established risk factors predisposing to thrombosis. Both disease entities are correlated with increased incidence of venous thrombotic events through multifaceted pathogenic mechanisms involving the interaction of cancer cells or SARS-CoV2 on the one hand and the coagulation system and endothelial cells on the other hand. Thromboprophylaxis is recommended for hospitalized patients with active cancer and high-risk outpatients with cancer receiving anticancer treatment. Universal thromboprophylaxis with a high prophylactic dose of low molecular weight heparins (LMWH) or therapeutic dose in select patients, is currentlyindicated for hospitalized patients with COVID-19. Also, prophylactic anticoagulation is recommended for outpatients with COVID-19 at high risk for thrombosis or disease worsening. However, whether there is an additive risk of thrombosis when a patient with cancer is infected with SARS-CoV2 remains unclear In the current review, we summarize and critically discuss the literature regarding the epidemiology of thrombotic events in patients with cancer and concomitant COVID-19, the thrombotic risk assessment, and the recommendations on thromboprophylaxis for this subgroup of patients. Current data do not support an additive thrombotic risk for patients with cancer and COVID-19. Of note, patients with cancer have less access to intensive care unit care, a setting associated with high thrombotic risk. Based on current evidence, patients with cancer and COVID-19 should be assessed with well-established risk assessment models for medically ill patients and receive thromboprophylaxis, preferentially with LMWH, according to existing recommendations. Prospective trials on well-characterized populations do not exist | ||
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700 | 1 | |a Brodmann, Marianne |e investigator |4 oth | |
700 | 1 | |a Carpentier, Patrick |e investigator |4 oth | |
700 | 1 | |a Celovska, Denisa |e investigator |4 oth | |
700 | 1 | |a De Marchi, Sergio |e investigator |4 oth | |
700 | 1 | |a Dimitrov, Gabriel |e investigator |4 oth | |
700 | 1 | |a Farkas, Katalin |e investigator |4 oth | |
700 | 1 | |a Fionik, Olga |e investigator |4 oth | |
700 | 1 | |a Fyta, Eleni |e investigator |4 oth | |
700 | 1 | |a Gkiozos, Ioannis |e investigator |4 oth | |
700 | 1 | |a Gottsater, Anders |e investigator |4 oth | |
700 | 1 | |a Gresele, Paolo |e investigator |4 oth | |
700 | 1 | |a Hamade, Amer |e investigator |4 oth | |
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700 | 1 | |a Pillon, Sergio |e investigator |4 oth | |
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700 | 1 | |a Visona, Adriana |e investigator |4 oth | |
700 | 1 | |a Xhepa, Sokol |e investigator |4 oth | |
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