In-hospital mortality of critically Ill patients with interactions of acute kidney injury and acute respiratory failure in the resource-limited settings : Results from SEA-AKI study
Copyright © 2022 Elsevier Inc. All rights reserved..
PURPOSE: Our goal was to describe clinical outcomes and explore the physiological interactions between acute kidney injury (AKI) and acute respiratory failure (ARF) in critically ill patients.
MATERIALS AND METHODS: Data were retrieved from the SEA-AKI study, a multinational multicenter database of adult ICUs from Thailand, Laos, and Indonesia. AKI was defined using KDIGO criteria stage 2-3. ARF was defined by being mechanically ventilated. Patients were assigned into 6 patterns based on AKI and ARF sequence: "no AKI/ARF", "ARF alone", "AKI alone", "ARF first", "AKI first", and "Concurrent AKI-ARF". The primary outcome was in-hospital mortality of each pattern.
RESULTS: A final cohort of 5468 patients were eligible for the analysis. The "Concurrent AKI-ARF" had the highest in-hospital mortality of 69.6%. The "AKI first" and the "ARF first" had in-hospital mortality of 54.4% and 53%, respectively. Among patients with single organ failure, in-hospital mortality was 14.6% and 31.5% in the "AKI alone" and the "ARF alone", accordingly. In-hospital mortality was 12.4% in patients without AKI and ARF.
CONCLUSION: Critically ill patients with ARF and AKI are at higher risk of in-hospital death. Different patterns of AKI and ARF interaction result in unique clinical outcomes as well as risk factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:71 |
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| Enthalten in: |
Journal of critical care - 71(2022) vom: 02. Okt., Seite 154103 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kulvichit, Win [VerfasserIn] |
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| Links: |
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| Themen: |
Acute kidney injury |
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| Anmerkungen: |
Date Completed 02.09.2022 Date Revised 01.11.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jcrc.2022.154103 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM343001489 |
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| 100 | 1 | |a Kulvichit, Win |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a In-hospital mortality of critically Ill patients with interactions of acute kidney injury and acute respiratory failure in the resource-limited settings |b Results from SEA-AKI study |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 01.11.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a PURPOSE: Our goal was to describe clinical outcomes and explore the physiological interactions between acute kidney injury (AKI) and acute respiratory failure (ARF) in critically ill patients | ||
| 520 | |a MATERIALS AND METHODS: Data were retrieved from the SEA-AKI study, a multinational multicenter database of adult ICUs from Thailand, Laos, and Indonesia. AKI was defined using KDIGO criteria stage 2-3. ARF was defined by being mechanically ventilated. Patients were assigned into 6 patterns based on AKI and ARF sequence: "no AKI/ARF", "ARF alone", "AKI alone", "ARF first", "AKI first", and "Concurrent AKI-ARF". The primary outcome was in-hospital mortality of each pattern | ||
| 520 | |a RESULTS: A final cohort of 5468 patients were eligible for the analysis. The "Concurrent AKI-ARF" had the highest in-hospital mortality of 69.6%. The "AKI first" and the "ARF first" had in-hospital mortality of 54.4% and 53%, respectively. Among patients with single organ failure, in-hospital mortality was 14.6% and 31.5% in the "AKI alone" and the "ARF alone", accordingly. In-hospital mortality was 12.4% in patients without AKI and ARF | ||
| 520 | |a CONCLUSION: Critically ill patients with ARF and AKI are at higher risk of in-hospital death. Different patterns of AKI and ARF interaction result in unique clinical outcomes as well as risk factors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Acute kidney injury | |
| 650 | 4 | |a Acute respiratory failure | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Intensive care unit | |
| 700 | 1 | |a Sarnvanichpitak, Kittipon |e verfasserin |4 aut | |
| 700 | 1 | |a Peerapornratana, Sadudee |e verfasserin |4 aut | |
| 700 | 1 | |a Tungsanga, Somkanya |e verfasserin |4 aut | |
| 700 | 1 | |a Lumlertgul, Nuttha |e verfasserin |4 aut | |
| 700 | 1 | |a Praditpornsilpa, Kearkiat |e verfasserin |4 aut | |
| 700 | 1 | |a Tungsanga, Kriang |e verfasserin |4 aut | |
| 700 | 1 | |a Eiam-Ong, Somchai |e verfasserin |4 aut | |
| 700 | 1 | |a Kellum, John A |e verfasserin |4 aut | |
| 700 | 1 | |a Srisawat, Nattachai |e verfasserin |4 aut | |
| 700 | 0 | |a SEA-AKI study group |e verfasserin |4 aut | |
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