Protocol for three alternative paradigms to test spatial learning and memory in mice
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved..
Here, we describe three alternative paradigms to overcome the limitations of the most widely used spatial learning paradigm for rodents: the Morris water maze. We outline the preparation of behavioral testing rooms and mouse handling/habituation prior to testing. We then detail three spatial learning and memory tasks: the Barnes maze, active place avoidance, and novel object location tasks. These tests have been successfully used across multiple ages (from 2 to 24 months) in both wild-type and transgenic animals. For complete details on the use and execution of this protocol, please refer to Leiter et al. (2022).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
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| Enthalten in: |
STAR protocols - 3(2022), 3 vom: 16. Sept., Seite 101500 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Blackmore, Daniel G [VerfasserIn] |
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| Links: |
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| Themen: |
Behavior |
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| Anmerkungen: |
Date Completed 22.09.2022 Date Revised 29.09.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.xpro.2022.101500 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM342974157 |
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| 520 | |a Here, we describe three alternative paradigms to overcome the limitations of the most widely used spatial learning paradigm for rodents: the Morris water maze. We outline the preparation of behavioral testing rooms and mouse handling/habituation prior to testing. We then detail three spatial learning and memory tasks: the Barnes maze, active place avoidance, and novel object location tasks. These tests have been successfully used across multiple ages (from 2 to 24 months) in both wild-type and transgenic animals. For complete details on the use and execution of this protocol, please refer to Leiter et al. (2022) | ||
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