Introduction and Establishment of SARS-CoV-2 Gamma Variant in New York City in Early 2021
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
BACKGROUND: Monitoring the emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is an important public health objective. We investigated how the Gamma variant was established in New York City (NYC) in early 2021 in the presence of travel restrictions that aimed to prevent viral spread from Brazil, the country where the variant was first identified.
METHODS: We performed phylogeographic analysis on 15 967 Gamma sequences sampled between 10 March and 1 May 2021, to identify geographic sources of Gamma lineages introduced into NYC. We identified locally circulating Gamma transmission clusters and inferred the timing of their establishment in NYC.
RESULTS: We identified 16 phylogenetically distinct Gamma clusters established in NYC (cluster sizes ranged 2-108 genomes); most of them were introduced from Florida and Illinois and only 1 directly from Brazil. By the time the first Gamma case was reported by genomic surveillance in NYC on 10 March, the majority (57%) of circulating Gamma lineages had already been established in the city for at least 2 weeks.
CONCLUSIONS: Although travel from Brazil to the United States was restricted from May 2020 through the end of the study period, this restriction did not prevent Gamma from becoming established in NYC as most introductions occurred from domestic locations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:226 |
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| Enthalten in: |
The Journal of infectious diseases - 226(2022), 12 vom: 13. Dez., Seite 2142-2149 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vasylyeva, Tetyana I [VerfasserIn] |
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| Links: |
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| Themen: |
Gamma variant |
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| Anmerkungen: |
Date Completed 15.12.2022 Date Revised 25.02.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiac265 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Introduction and Establishment of SARS-CoV-2 Gamma Variant in New York City in Early 2021 |
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| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: Monitoring the emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is an important public health objective. We investigated how the Gamma variant was established in New York City (NYC) in early 2021 in the presence of travel restrictions that aimed to prevent viral spread from Brazil, the country where the variant was first identified | ||
| 520 | |a METHODS: We performed phylogeographic analysis on 15 967 Gamma sequences sampled between 10 March and 1 May 2021, to identify geographic sources of Gamma lineages introduced into NYC. We identified locally circulating Gamma transmission clusters and inferred the timing of their establishment in NYC | ||
| 520 | |a RESULTS: We identified 16 phylogenetically distinct Gamma clusters established in NYC (cluster sizes ranged 2-108 genomes); most of them were introduced from Florida and Illinois and only 1 directly from Brazil. By the time the first Gamma case was reported by genomic surveillance in NYC on 10 March, the majority (57%) of circulating Gamma lineages had already been established in the city for at least 2 weeks | ||
| 520 | |a CONCLUSIONS: Although travel from Brazil to the United States was restricted from May 2020 through the end of the study period, this restriction did not prevent Gamma from becoming established in NYC as most introductions occurred from domestic locations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 4 | |a Gamma variant | |
| 650 | 4 | |a New York City | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a public health | |
| 650 | 4 | |a travel restrictions | |
| 700 | 1 | |a Fang, Courtney E |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Michelle |e verfasserin |4 aut | |
| 700 | 1 | |a Havens, Jennifer L |e verfasserin |4 aut | |
| 700 | 1 | |a Parker, Edyth |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jade C |e verfasserin |4 aut | |
| 700 | 1 | |a Zeller, Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Yakovleva, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Hassler, Gabriel W |e verfasserin |4 aut | |
| 700 | 1 | |a Chowdhury, Moinuddin A |e verfasserin |4 aut | |
| 700 | 1 | |a Andersen, Kristian G |e verfasserin |4 aut | |
| 700 | 1 | |a Hughes, Scott |e verfasserin |4 aut | |
| 700 | 1 | |a Wertheim, Joel O |e verfasserin |4 aut | |
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