GaIIItriarylcorroles with push-pull substitutions : synthesis, electronic structure and biomedical applications
Two A2B type H3corroles and two GaIIItriarylcorroles with carbazole substitutions at 10-positions were synthesized and characterized. An analysis of structure-property relationships of the corroles has been carried out by investigating the optical spectroscopy of the dyes to trends predicted in DFT and TD-DFT calculations. Interestingly, the photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT) activity properties of the GaIIItriarylcorroles were determined against the MCF-7 breast cancer line, and Staphyloccocus aureus (S. aureus) and Escherichia coli (E. coli), respectively. The cationic G-2Q species exhibited the most favorable properties with an IC50 value of 7.8 μM against MCF-7 cells, and Log reduction values of 7.78 and 3.26 against planktonic S. aureus and E. coli at 0.5 and 10 μM, respectively.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
|---|---|
| Enthalten in: |
Dalton transactions (Cambridge, England : 2003) - 51(2022), 27 vom: 12. Juli, Seite 10543-10551 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Niu, Yingjie [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 13.07.2022 Date Revised 13.07.2022 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1039/d2dt01262f |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM342877860 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM342877860 | ||
| 003 | DE-627 | ||
| 005 | 20231226015126.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1039/d2dt01262f |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1142.xml |
| 035 | |a (DE-627)NLM342877860 | ||
| 035 | |a (NLM)35766908 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Niu, Yingjie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a GaIIItriarylcorroles with push-pull substitutions |b synthesis, electronic structure and biomedical applications |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 13.07.2022 | ||
| 500 | |a Date Revised 13.07.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Two A2B type H3corroles and two GaIIItriarylcorroles with carbazole substitutions at 10-positions were synthesized and characterized. An analysis of structure-property relationships of the corroles has been carried out by investigating the optical spectroscopy of the dyes to trends predicted in DFT and TD-DFT calculations. Interestingly, the photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT) activity properties of the GaIIItriarylcorroles were determined against the MCF-7 breast cancer line, and Staphyloccocus aureus (S. aureus) and Escherichia coli (E. coli), respectively. The cationic G-2Q species exhibited the most favorable properties with an IC50 value of 7.8 μM against MCF-7 cells, and Log reduction values of 7.78 and 3.26 against planktonic S. aureus and E. coli at 0.5 and 10 μM, respectively | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Wang, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Yingxin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Weihua |e verfasserin |4 aut | |
| 700 | 1 | |a Soy, Rodah C |e verfasserin |4 aut | |
| 700 | 1 | |a Babu, Balaji |e verfasserin |4 aut | |
| 700 | 1 | |a Mack, John |e verfasserin |4 aut | |
| 700 | 1 | |a Nyokong, Tebello |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Haijun |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Xu |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Dalton transactions (Cambridge, England : 2003) |d 2004 |g 51(2022), 27 vom: 12. Juli, Seite 10543-10551 |w (DE-627)NLM149339739 |x 1477-9234 |7 nnns |
| 773 | 1 | 8 | |g volume:51 |g year:2022 |g number:27 |g day:12 |g month:07 |g pages:10543-10551 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1039/d2dt01262f |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 51 |j 2022 |e 27 |b 12 |c 07 |h 10543-10551 | ||