Pinocembrin polymeric micellar drug delivery system : preparation, characterisation and anti-hyperuricemic activity evaluation
Aim: Hydrophobic pinocembrin (PCB) was incorporated into a new nano-drug delivery system to enhance solubility, bioavailability and anti-hyperuricemic activity of the drug.Methods: We fabricated PCB loaded polymeric micelles (PCB-FPM) by thin film dispersion method and appropriately determined their physical characteristics. The oral relative bioavailability and anti-hyperuricemic activity of PCB-FPM and free PCB were observed.Results: The optimum particle size of the micelles was 19.90 ± 0.93 nm. PCB-FPM exhibited great stability within 18 days, coupled with lower cytotoxicity and higher biocompatibility. Moreover, the percent cumulative release of PCB-FPM was much higher than free PCB in the dissolution media. The oral bioavailability of PCB-FPM was increased by 2.61 times compared with free PCB. Uric acid (UA) level of rats was reduced in PCB-FPM group (200 mg/kg) by 78.82% comparable to the model control.Conclusion: PCB-FPM may become an ideal strategy to increase oral in-vivo availability and anti-hyperuricemic activity of PCB.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Journal of microencapsulation - 39(2022), 5 vom: 13. Aug., Seite 419-432 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rong, Wanjing [VerfasserIn] |
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| Links: |
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| Themen: |
8T7C8CH791 |
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| Anmerkungen: |
Date Completed 08.09.2022 Date Revised 08.09.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2022.2096138 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM342872095 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: Hydrophobic pinocembrin (PCB) was incorporated into a new nano-drug delivery system to enhance solubility, bioavailability and anti-hyperuricemic activity of the drug.Methods: We fabricated PCB loaded polymeric micelles (PCB-FPM) by thin film dispersion method and appropriately determined their physical characteristics. The oral relative bioavailability and anti-hyperuricemic activity of PCB-FPM and free PCB were observed.Results: The optimum particle size of the micelles was 19.90 ± 0.93 nm. PCB-FPM exhibited great stability within 18 days, coupled with lower cytotoxicity and higher biocompatibility. Moreover, the percent cumulative release of PCB-FPM was much higher than free PCB in the dissolution media. The oral bioavailability of PCB-FPM was increased by 2.61 times compared with free PCB. Uric acid (UA) level of rats was reduced in PCB-FPM group (200 mg/kg) by 78.82% comparable to the model control.Conclusion: PCB-FPM may become an ideal strategy to increase oral in-vivo availability and anti-hyperuricemic activity of PCB | ||
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| 700 | 1 | |a He, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaoxiao |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Xiaoli |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Ji, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Toreniyazov, Elmurat |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Qilong |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Jiangnan |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Ximing |e verfasserin |4 aut | |
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