pH-responsive glucosamine anchored polydopamine coated mesoporous silica nanoparticles for delivery of Anderson-type polyoxomolybdate in breast cancer
AIM: This study aimed to develop novel pH-sensitive Glucosamine (Glu) targeted Polydopamine (PDA) coated mesoporous silica (SBA-15) nanoparticles (NPs) for selective delivery of anticancer Anderson-type manganese polyoxomolybdate (POMo) to breast cancer.
METHODS: The POMoSBA-PDA-Glu NPs were prepared via direct hydrothermal synthesis of SBA, POMo loading, in situ PDA post functionalization, and Glu anchoring; the chemical structures were fully studied by different characterisation methods. The anticancer activity was studied by MTT method and Annexin V-FITC apoptosis detection kit.
RESULTS: The optimised NPs had a hydrodynamic size (HS) of 195 nm, a zeta potential (ZP) of -18.9 mV, a loading content percent (LC%) of 45%, and a pH-responsive release profile. The targeted NPs showed increased anticancer activity against breast cancer cell lines compared to the free POMo with the highest cellular uptake and apoptosis level in the MDA-MB-231 cells.
CONCLUSIONS: POMoSBA-PDA-Glu NPs could be a promising anticancer candidate for further studies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Journal of microencapsulation - 39(2022), 5 vom: 19. Aug., Seite 433-451 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ramezani-Aliakbari, Maryam [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 08.09.2022 Date Revised 08.09.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2022.2096139 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM342838636 |
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| 100 | 1 | |a Ramezani-Aliakbari, Maryam |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a pH-responsive glucosamine anchored polydopamine coated mesoporous silica nanoparticles for delivery of Anderson-type polyoxomolybdate in breast cancer |
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| 500 | |a Date Completed 08.09.2022 | ||
| 500 | |a Date Revised 08.09.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: This study aimed to develop novel pH-sensitive Glucosamine (Glu) targeted Polydopamine (PDA) coated mesoporous silica (SBA-15) nanoparticles (NPs) for selective delivery of anticancer Anderson-type manganese polyoxomolybdate (POMo) to breast cancer | ||
| 520 | |a METHODS: The POMoSBA-PDA-Glu NPs were prepared via direct hydrothermal synthesis of SBA, POMo loading, in situ PDA post functionalization, and Glu anchoring; the chemical structures were fully studied by different characterisation methods. The anticancer activity was studied by MTT method and Annexin V-FITC apoptosis detection kit | ||
| 520 | |a RESULTS: The optimised NPs had a hydrodynamic size (HS) of 195 nm, a zeta potential (ZP) of -18.9 mV, a loading content percent (LC%) of 45%, and a pH-responsive release profile. The targeted NPs showed increased anticancer activity against breast cancer cell lines compared to the free POMo with the highest cellular uptake and apoptosis level in the MDA-MB-231 cells | ||
| 520 | |a CONCLUSIONS: POMoSBA-PDA-Glu NPs could be a promising anticancer candidate for further studies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anderson-type manganese polyoxomolybdate (POMo) | |
| 650 | 4 | |a anticancer activity | |
| 650 | 4 | |a barbara amorphous-15 mesoporous Silica (SBA-15) | |
| 650 | 4 | |a nanoparticles (NPs) | |
| 650 | 4 | |a polydopamine (PDA) | |
| 650 | 4 | |a targeted drug delivery | |
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| 700 | 1 | |a Mirian, Mina |e verfasserin |4 aut | |
| 700 | 1 | |a Khodarahmi, Ghadamali |e verfasserin |4 aut | |
| 700 | 1 | |a Rostami, Mahboubeh |e verfasserin |4 aut | |
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