Impact of allogeneic red blood cell transfusion on prognosis in soft tissue sarcoma patients. A single-centre study
© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd..
BACKGROUND: Perioperatively administered (leukocyte reduced) allogeneic red blood cell transfusions (lrRBCTs) may lead to transfusion-related immunomodulation and reduced overall survival (OS) in cancer patients. Herein, the effect of lrRBCT on local recurrence (LR), distant metastasis (DM), and OS in soft tissue sarcoma (STS) patients was analysed.
METHODS: Retrospective study on 432 STS patients (mean age: 60.0 ± 17.8 years; 46.1% female), surgically treated at a tertiary tumour centre. Uni- and multivariate survival models were calculated to analyse impact of perioperative lrRBCTs on LR, DM, OS.
RESULTS: Perioperatively, 75 patients (17.4%) had received lrRBCTs. Older patients, deep, large, lower limb STS rather required lrRBCTs (all p < 0.05). No significant association between lrRBCT administration and LR- (p = 0.582) or DM-risk (p = 0.084) was observed. LrRBCT was associated with worse OS in univariate analysis (HR: 2.222; p < 0.001), with statistical significance lost upon multivariate analysis (HR: 1.658; p = 0.059; including age, histology, size, grading, amputation, depth). Adding preoperative haemoglobin in subgroup of 220 patients with laboratory parameters revealed significant negative impact of low haemoglobin on OS (p = 0.014), whilst effect of lrRBCT was further diminished (p = 0.167).
CONCLUSION: Unfavourable prognostic factors prevail in STS patients requiring lrRBCTs. Low haemoglobin levels rather than lrRBCT seem to reduce OS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Cancer medicine - 12(2023), 2 vom: 31. Jan., Seite 1237-1246 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Smolle, Maria Anna [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 31.01.2023 Date Revised 26.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/cam4.4989 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM342831496 |
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| 245 | 1 | 0 | |a Impact of allogeneic red blood cell transfusion on prognosis in soft tissue sarcoma patients. A single-centre study |
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| 500 | |a Date Revised 26.02.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: Perioperatively administered (leukocyte reduced) allogeneic red blood cell transfusions (lrRBCTs) may lead to transfusion-related immunomodulation and reduced overall survival (OS) in cancer patients. Herein, the effect of lrRBCT on local recurrence (LR), distant metastasis (DM), and OS in soft tissue sarcoma (STS) patients was analysed | ||
| 520 | |a METHODS: Retrospective study on 432 STS patients (mean age: 60.0 ± 17.8 years; 46.1% female), surgically treated at a tertiary tumour centre. Uni- and multivariate survival models were calculated to analyse impact of perioperative lrRBCTs on LR, DM, OS | ||
| 520 | |a RESULTS: Perioperatively, 75 patients (17.4%) had received lrRBCTs. Older patients, deep, large, lower limb STS rather required lrRBCTs (all p < 0.05). No significant association between lrRBCT administration and LR- (p = 0.582) or DM-risk (p = 0.084) was observed. LrRBCT was associated with worse OS in univariate analysis (HR: 2.222; p < 0.001), with statistical significance lost upon multivariate analysis (HR: 1.658; p = 0.059; including age, histology, size, grading, amputation, depth). Adding preoperative haemoglobin in subgroup of 220 patients with laboratory parameters revealed significant negative impact of low haemoglobin on OS (p = 0.014), whilst effect of lrRBCT was further diminished (p = 0.167) | ||
| 520 | |a CONCLUSION: Unfavourable prognostic factors prevail in STS patients requiring lrRBCTs. Low haemoglobin levels rather than lrRBCT seem to reduce OS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a soft tissue sarcoma | |
| 650 | 4 | |a surgery | |
| 650 | 4 | |a surgical oncology | |
| 700 | 1 | |a Helmberg, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Matzhold, Eva Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Barth, Dominik Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Sareban, Nazanin |e verfasserin |4 aut | |
| 700 | 1 | |a Szkandera, Joanna |e verfasserin |4 aut | |
| 700 | 1 | |a Liegl-Atzwanger, Bernadette |e verfasserin |4 aut | |
| 700 | 1 | |a Leithner, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Pichler, Martin |e verfasserin |4 aut | |
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