Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia : A Case-Control Study
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
In this case-control study, we evaluated the association between serum antibodies against hepatitis E virus (HEV) and central nervous system (CNS) neurodegenerative disorders (NDs) in older people with dementia. The presence of anti-HEV antibodies was related to a higher adjusted odds ratio (aOR) of having CNS NDs by neuropathological diagnosis (aOR, 2.13; P = .007) and clinical/neuropathological diagnosis (1.84; P = .02). Besides, serum anti-HEV antibodies were directly related to neuropathological injury (higher vascular pathology [aOR, 1.97; P = .006]) and higher probability of Alzheimer-type pathology (1.84; P = .02). In conclusion, the presence of anti-HEV antibodies was related to higher odds of CNS NDs and neuropathological injury in older people.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:227 |
|---|---|
| Enthalten in: |
The Journal of infectious diseases - 227(2023), 7 vom: 12. Apr., Seite 873-877 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Pérez-García, Felipe [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Alzheimer |
|---|
| Anmerkungen: |
Date Completed 14.04.2023 Date Revised 15.06.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/infdis/jiac268 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM342802119 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM342802119 | ||
| 003 | DE-627 | ||
| 005 | 20231226014945.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/infdis/jiac268 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1142.xml |
| 035 | |a (DE-627)NLM342802119 | ||
| 035 | |a (NLM)35759220 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Pérez-García, Felipe |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia |b A Case-Control Study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.04.2023 | ||
| 500 | |a Date Revised 15.06.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a In this case-control study, we evaluated the association between serum antibodies against hepatitis E virus (HEV) and central nervous system (CNS) neurodegenerative disorders (NDs) in older people with dementia. The presence of anti-HEV antibodies was related to a higher adjusted odds ratio (aOR) of having CNS NDs by neuropathological diagnosis (aOR, 2.13; P = .007) and clinical/neuropathological diagnosis (1.84; P = .02). Besides, serum anti-HEV antibodies were directly related to neuropathological injury (higher vascular pathology [aOR, 1.97; P = .006]) and higher probability of Alzheimer-type pathology (1.84; P = .02). In conclusion, the presence of anti-HEV antibodies was related to higher odds of CNS NDs and neuropathological injury in older people | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Alzheimer | |
| 650 | 4 | |a Hepatitis E virus | |
| 650 | 4 | |a neurodegenerative disorders | |
| 650 | 4 | |a older people | |
| 650 | 4 | |a seroprevalence | |
| 650 | 4 | |a vascular pathology | |
| 650 | 7 | |a Hepatitis Antibodies |2 NLM | |
| 650 | 7 | |a Immunoglobulin M |2 NLM | |
| 700 | 1 | |a Vázquez-Morón, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a Burgueño-García, Iván |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz-Gómez, María José |e verfasserin |4 aut | |
| 700 | 1 | |a Zea-Sevilla, María Ascensión |e verfasserin |4 aut | |
| 700 | 1 | |a Calero, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez, Isidoro |e verfasserin |4 aut | |
| 700 | 1 | |a Rábano, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Resino, Salvador |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of infectious diseases |d 1945 |g 227(2023), 7 vom: 12. Apr., Seite 873-877 |w (DE-627)NLM000005819 |x 1537-6613 |7 nnns |
| 773 | 1 | 8 | |g volume:227 |g year:2023 |g number:7 |g day:12 |g month:04 |g pages:873-877 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/infdis/jiac268 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 227 |j 2023 |e 7 |b 12 |c 04 |h 873-877 | ||