Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly : a systematic review and meta-analysis of clinical trials
© 2022. The Author(s)..
BACKGROUND: There has been a longstanding interest in the potential effect of vitamin D in preventing cardiac-metabolic diseases. However, there are divergent results regarding the impact of vitamin D supplementation (VDS) on managing cardiac-metabolic outcomes in the elderly population.
MATERIAL AND METHOD: We systematically searched electronic databases; Web of Science, PubMed, Scopus, EMBASE, Cochrane, and ProQuest. We included all trials that evaluated the effect of VDS on cardiac-metabolic risk factors in the elderly population, which were published until 30 September 2021. The effects of VDS on cardiac-metabolic outcomes were assessed using standardized mean difference (SMD). A random-effect model was used to pool the SMD and 95% confidence interval (CI).
RESULT: The literature search identified 4409 studies, of which 12 trials met inclusion criteria. Results of random effect meta-analysis indicated a significant reduction in total cholesterol (TC) (SMD: - 0.14 mg/dl; 95% CI: - 0.25, - 0.02) and triglyceride (TG) (SMD: - 0.45 mg/dl; 95% CI: - 0.86, - 0.04) with VDS compared to the placebo. The subgroup analyses revealed that the reduction of TG in patients with diabetes and vitamin D deficiency was significant. Furthermore, short-term intervention (≤ 6 months) induced a significantly lower level of TG and insulin in comparison to longer duration (> 6 months).
CONCLUSION: The study suggests that VDS could improve insulin concentration and dyslipidemia in the elderly population. The systematic review was registered in Alborz university of medical sciences with 2060-01-03-1397 number and the Ethics council IR.ABZUMS.REC.1397.207 number.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Diabetology & metabolic syndrome - 14(2022), 1 vom: 25. Juni, Seite 88 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Qorbani, Mostafa [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiac-metabolic |
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| Anmerkungen: |
Date Revised 16.07.2022 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1186/s13098-022-00859-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM342738534 |
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| 520 | |a © 2022. The Author(s). | ||
| 520 | |a BACKGROUND: There has been a longstanding interest in the potential effect of vitamin D in preventing cardiac-metabolic diseases. However, there are divergent results regarding the impact of vitamin D supplementation (VDS) on managing cardiac-metabolic outcomes in the elderly population | ||
| 520 | |a MATERIAL AND METHOD: We systematically searched electronic databases; Web of Science, PubMed, Scopus, EMBASE, Cochrane, and ProQuest. We included all trials that evaluated the effect of VDS on cardiac-metabolic risk factors in the elderly population, which were published until 30 September 2021. The effects of VDS on cardiac-metabolic outcomes were assessed using standardized mean difference (SMD). A random-effect model was used to pool the SMD and 95% confidence interval (CI) | ||
| 520 | |a RESULT: The literature search identified 4409 studies, of which 12 trials met inclusion criteria. Results of random effect meta-analysis indicated a significant reduction in total cholesterol (TC) (SMD: - 0.14 mg/dl; 95% CI: - 0.25, - 0.02) and triglyceride (TG) (SMD: - 0.45 mg/dl; 95% CI: - 0.86, - 0.04) with VDS compared to the placebo. The subgroup analyses revealed that the reduction of TG in patients with diabetes and vitamin D deficiency was significant. Furthermore, short-term intervention (≤ 6 months) induced a significantly lower level of TG and insulin in comparison to longer duration (> 6 months) | ||
| 520 | |a CONCLUSION: The study suggests that VDS could improve insulin concentration and dyslipidemia in the elderly population. The systematic review was registered in Alborz university of medical sciences with 2060-01-03-1397 number and the Ethics council IR.ABZUMS.REC.1397.207 number | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cardiac-metabolic | |
| 650 | 4 | |a Elderly | |
| 650 | 4 | |a Supplementation | |
| 650 | 4 | |a Vitamin D | |
| 700 | 1 | |a Zarei, Maryam |e verfasserin |4 aut | |
| 700 | 1 | |a Moradi, Yousef |e verfasserin |4 aut | |
| 700 | 1 | |a Appannah, Geeta |e verfasserin |4 aut | |
| 700 | 1 | |a Djalainia, Shirin |e verfasserin |4 aut | |
| 700 | 1 | |a Pourrostami, Kumars |e verfasserin |4 aut | |
| 700 | 1 | |a Ejtahed, Hanieh-Sadat |e verfasserin |4 aut | |
| 700 | 1 | |a Mahdavi-Gorabi, Armita |e verfasserin |4 aut | |
| 700 | 1 | |a Naderali, Ebrahim Khalil |e verfasserin |4 aut | |
| 700 | 1 | |a Khazdouz, Maryam |e verfasserin |4 aut | |
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