Anti-inflammatory abietanes diterpenes and triterpenoids isolated from Clinopodium polycephalum
Copyright © 2022 Elsevier B.V. All rights reserved..
Two previously undescribed diterpenes (1 and 2), as well as one curious triterpenoid were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses, UV spectrum, and extensive 2D-homo and heteronuclear NMR data interpretations. Among them, 1 had an unusual skeletal characteristic produced by a rare methyl migration pathway. All monomer compounds exhibited inhibitory effects on NO production in LPS-induced RAW 264.7 cells without affecting cell viabilities, which were comparable to that of positive control.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:161 |
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| Enthalten in: |
Fitoterapia - 161(2022) vom: 01. Sept., Seite 105244 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Yaxuan [VerfasserIn] |
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| Links: |
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| Themen: |
Abietane diterpenoids |
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| Anmerkungen: |
Date Completed 23.08.2022 Date Revised 23.08.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fitote.2022.105244 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Two previously undescribed diterpenes (1 and 2), as well as one curious triterpenoid were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses, UV spectrum, and extensive 2D-homo and heteronuclear NMR data interpretations. Among them, 1 had an unusual skeletal characteristic produced by a rare methyl migration pathway. All monomer compounds exhibited inhibitory effects on NO production in LPS-induced RAW 264.7 cells without affecting cell viabilities, which were comparable to that of positive control | ||
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| 700 | 1 | |a Xu, Jixuan |e verfasserin |4 aut | |
| 700 | 1 | |a Bi, Guangming |e verfasserin |4 aut | |
| 700 | 1 | |a Meng, Dali |e verfasserin |4 aut | |
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