Clinicopathological Characteristics of Nonfunctional Pancreatic Neuroendocrine Neoplasms and the Effect of Surgical Treatment on the Prognosis of Patients with Liver Metastases : A Study Based on the SEER Database
Copyright © 2022 Abuduhaibaier Sadula et al..
Background: The incidence of nonfunctional pancreatic neuroendocrine neoplasms (NF-pNENs) has been increasing annually. This study is aimed at investigating the clinicopathological characteristics and high-risk factors of NF-pNENs and the influence of surgical treatment on the prognosis of NF-pNEN patients with liver metastases.
Methods: pNEN patients in this study were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. This study analyzed patients diagnosed with NF-pNENs from 2000 to 2017 who met the inclusion criteria. A retrospective analysis of the clinicopathological characteristics of NF-pNEN patients was conducted. Kaplan-Meier method was used to calculate the survival time. A multivariate Cox regression model was used to analyze the survival outcomes and risk factors.
Results: From 2000 to 2017, the SEER database registered 10576 patients with pNENs and 1774 patients with liver metastases. Cox analysis revealed that age, sex, primary site, grade, tumor stage, surgery, tumor size, and liver metastasis were risk factors of prognosis, with grade being the most influential index. Patients with NF-pNENs with liver metastasis and no metastasis had different primary site, grade, and tumor size. In general, a higher grade was associated with a larger tumor and a greater risk of liver metastasis. Meanwhile, patients with liver metastasis showed that those with tumors originated from the tail of the pancreas had better prognoses than those with tumors originated from other parts. Surgical treatment can improve the prognosis of patients with liver metastases, despite the tumor grade.
Conclusions: The incidence of pNENs has been increasing annually, and the liver has been the most common site of metastasis. Liver metastasis in patients with NF-pNENs, related to tumor size and grade, affected their long-term survival. Surgery significantly improved the prognosis of patients with liver metastases secondary to NF-pNENs with different grades.
| Errataetall: |
RetractionIn: Comput Math Methods Med. 2023 Jun 28;2023:9793403. - PMID 37416204 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2022 |
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| Enthalten in: |
Computational and mathematical methods in medicine - 2022(2022) vom: 16., Seite 3689895 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sadula, Abuduhaibaier [VerfasserIn] |
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Date Completed 21.06.2022 Date Revised 07.07.2023 published: Electronic-eCollection RetractionIn: Comput Math Methods Med. 2023 Jun 28;2023:9793403. - PMID 37416204 Citation Status MEDLINE |
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| doi: |
10.1155/2022/3689895 |
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| PPN (Katalog-ID): |
NLM342413015 |
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| 245 | 1 | 0 | |a Clinicopathological Characteristics of Nonfunctional Pancreatic Neuroendocrine Neoplasms and the Effect of Surgical Treatment on the Prognosis of Patients with Liver Metastases |b A Study Based on the SEER Database |
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| 500 | |a Date Revised 07.07.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a RetractionIn: Comput Math Methods Med. 2023 Jun 28;2023:9793403. - PMID 37416204 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Abuduhaibaier Sadula et al. | ||
| 520 | |a Background: The incidence of nonfunctional pancreatic neuroendocrine neoplasms (NF-pNENs) has been increasing annually. This study is aimed at investigating the clinicopathological characteristics and high-risk factors of NF-pNENs and the influence of surgical treatment on the prognosis of NF-pNEN patients with liver metastases | ||
| 520 | |a Methods: pNEN patients in this study were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. This study analyzed patients diagnosed with NF-pNENs from 2000 to 2017 who met the inclusion criteria. A retrospective analysis of the clinicopathological characteristics of NF-pNEN patients was conducted. Kaplan-Meier method was used to calculate the survival time. A multivariate Cox regression model was used to analyze the survival outcomes and risk factors | ||
| 520 | |a Results: From 2000 to 2017, the SEER database registered 10576 patients with pNENs and 1774 patients with liver metastases. Cox analysis revealed that age, sex, primary site, grade, tumor stage, surgery, tumor size, and liver metastasis were risk factors of prognosis, with grade being the most influential index. Patients with NF-pNENs with liver metastasis and no metastasis had different primary site, grade, and tumor size. In general, a higher grade was associated with a larger tumor and a greater risk of liver metastasis. Meanwhile, patients with liver metastasis showed that those with tumors originated from the tail of the pancreas had better prognoses than those with tumors originated from other parts. Surgical treatment can improve the prognosis of patients with liver metastases, despite the tumor grade | ||
| 520 | |a Conclusions: The incidence of pNENs has been increasing annually, and the liver has been the most common site of metastasis. Liver metastasis in patients with NF-pNENs, related to tumor size and grade, affected their long-term survival. Surgery significantly improved the prognosis of patients with liver metastases secondary to NF-pNENs with different grades | ||
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| 700 | 1 | |a Xiu, Dianrong |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Chen |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Siqian |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, Chunhui |e verfasserin |4 aut | |
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