Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
BACKGROUND: Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients.
METHODS: We compared demographics, clinical characteristics, and outcomes of US children (aged 8 months to 17 years) admitted to the intensive care or high-acuity unit with influenza or COVID-19. Using mixed-effects models, we assessed the odds of death or requiring life support for influenza vs COVID-19 after adjustment for age, sex, race and Hispanic origin, and underlying conditions including obesity.
RESULTS: Children with influenza (n = 179) were younger than those with COVID-19 (n = 381; median, 5.2 years vs 13.8 years), less likely to be non-Hispanic Black (14.5% vs 27.6%) or Hispanic (24.0% vs 36.2%), and less likely to have ≥1 underlying condition (66.4% vs 78.5%) or be obese (21.4% vs 42.2%), and a shorter hospital stay (median, 5 days vs 7 days). They were similarly likely to require invasive mechanical ventilation (both 30.2%), vasopressor support (19.6% and 19.9%), or extracorporeal membrane oxygenation (2.2% and 2.9%). Four children with influenza (2.2%) and 11 children with COVID-19 (2.9%) died. The odds of death or requiring life support in children with influenza vs COVID-19 were similar (adjusted odds ratio, 1.30; 95% confidence interval, .78-2.15; P = .32).
CONCLUSIONS: Despite differences in demographics and clinical characteristics of children with influenza or COVID-19, the frequency of life-threatening complications was similar. Our findings highlight the importance of implementing prevention measures to reduce transmission and disease severity of influenza and COVID-19.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
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Enthalten in: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 76(2023), 3 vom: 08. Feb., Seite e280-e290 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Halasa, Natasha B [VerfasserIn] |
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Links: |
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Themen: |
COVID-19 |
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Anmerkungen: |
Date Completed 10.02.2023 Date Revised 29.09.2023 published: Print Citation Status MEDLINE |
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doi: |
10.1093/cid/ciac477 |
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funding: |
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520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
520 | |a BACKGROUND: Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients | ||
520 | |a METHODS: We compared demographics, clinical characteristics, and outcomes of US children (aged 8 months to 17 years) admitted to the intensive care or high-acuity unit with influenza or COVID-19. Using mixed-effects models, we assessed the odds of death or requiring life support for influenza vs COVID-19 after adjustment for age, sex, race and Hispanic origin, and underlying conditions including obesity | ||
520 | |a RESULTS: Children with influenza (n = 179) were younger than those with COVID-19 (n = 381; median, 5.2 years vs 13.8 years), less likely to be non-Hispanic Black (14.5% vs 27.6%) or Hispanic (24.0% vs 36.2%), and less likely to have ≥1 underlying condition (66.4% vs 78.5%) or be obese (21.4% vs 42.2%), and a shorter hospital stay (median, 5 days vs 7 days). They were similarly likely to require invasive mechanical ventilation (both 30.2%), vasopressor support (19.6% and 19.9%), or extracorporeal membrane oxygenation (2.2% and 2.9%). Four children with influenza (2.2%) and 11 children with COVID-19 (2.9%) died. The odds of death or requiring life support in children with influenza vs COVID-19 were similar (adjusted odds ratio, 1.30; 95% confidence interval, .78-2.15; P = .32) | ||
520 | |a CONCLUSIONS: Despite differences in demographics and clinical characteristics of children with influenza or COVID-19, the frequency of life-threatening complications was similar. Our findings highlight the importance of implementing prevention measures to reduce transmission and disease severity of influenza and COVID-19 | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a SARS-CoV-2 | |
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700 | 1 | |a Schuster, Jennifer E |e verfasserin |4 aut | |
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700 | 1 | |a McLaughlin, Gwenn E |e verfasserin |4 aut | |
700 | 1 | |a Hobbs, Charlotte V |e verfasserin |4 aut | |
700 | 1 | |a Rowan, Courtney M |e verfasserin |4 aut | |
700 | 1 | |a Bembea, Melania M |e verfasserin |4 aut | |
700 | 1 | |a Nofziger, Ryan A |e verfasserin |4 aut | |
700 | 1 | |a Babbitt, Christopher J |e verfasserin |4 aut | |
700 | 1 | |a Bowens, Cindy |e verfasserin |4 aut | |
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700 | 1 | |a Cvijanovich, Natalie Z |e verfasserin |4 aut | |
700 | 1 | |a Singh, Aalok R |e verfasserin |4 aut | |
700 | 1 | |a Crandall, Hillary A |e verfasserin |4 aut | |
700 | 1 | |a Thomas, Neal J |e verfasserin |4 aut | |
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700 | 1 | |a Katherine, Irby |e investigator |4 oth | |
700 | 1 | |a Peter, Mourani |e investigator |4 oth | |
700 | 1 | |a Schwarz, Adam J |e investigator |4 oth | |
700 | 1 | |a Babbitt, Christopher J |e investigator |4 oth | |
700 | 1 | |a Helen, Harvey |e investigator |4 oth | |
700 | 1 | |a Cvijanovich, Natalie Z |e investigator |4 oth | |
700 | 1 | |a Zinter, Matt S |e investigator |4 oth | |
700 | 1 | |a Maddux, Aline B |e investigator |4 oth | |
700 | 1 | |a Osborne, Christina M |e investigator |4 oth | |
700 | 1 | |a Sara, Shankman |e investigator |4 oth | |
700 | 1 | |a Mourani, Peter M |e investigator |4 oth | |
700 | 1 | |a Emily, Port |e investigator |4 oth | |
700 | 1 | |a Van, Kevin A |e investigator |4 oth | |
700 | 1 | |a Carroll, Christopher L |e investigator |4 oth | |
700 | 1 | |a Giuliano, John S |e investigator |4 oth | |
700 | 1 | |a McLaughlin, Gwenn E |e investigator |4 oth | |
700 | 1 | |a Tarquinio, Keiko M |e investigator |4 oth | |
700 | 1 | |a Michelson, Kelly N |e investigator |4 oth | |
700 | 1 | |a Coates, Bria M |e investigator |4 oth | |
700 | 1 | |a Rowan, Courtney M |e investigator |4 oth | |
700 | 1 | |a Wellnitz, Kari |e investigator |4 oth | |
700 | 1 | |a Bhoojhawon, Guru |e investigator |4 oth | |
700 | 1 | |a Sullivan, Janice E |e investigator |4 oth | |
700 | 1 | |a Montgomery, Vicki L |e investigator |4 oth | |
700 | 1 | |a Havlin, Kevin M |e investigator |4 oth | |
700 | 1 | |a Bradford, Tamara T |e investigator |4 oth | |
700 | 1 | |a Riggs, Becky J |e investigator |4 oth | |
700 | 1 | |a Bembea, Melania M |e investigator |4 oth | |
700 | 1 | |a Randolph, Adrienne G |e investigator |4 oth | |
700 | 1 | |a Newhams, Margaret M |e investigator |4 oth | |
700 | 1 | |a Chen, Sabrina R |e investigator |4 oth | |
700 | 1 | |a Young, Cameron C |e investigator |4 oth | |
700 | 1 | |a Moffitt, Kristin L |e investigator |4 oth | |
700 | 1 | |a Nakamura, Mari M |e investigator |4 oth | |
700 | 1 | |a Carroll, Ryan W |e investigator |4 oth | |
700 | 1 | |a Yager, Phoebe H |e investigator |4 oth | |
700 | 1 | |a Fernandes, Neil D |e investigator |4 oth | |
700 | 1 | |a Flori, Heidi R |e investigator |4 oth | |
700 | 1 | |a Heidemann, Sabrina M |e investigator |4 oth | |
700 | 1 | |a Hume, Janet R |e investigator |4 oth | |
700 | 1 | |a Levy, Emily R |e investigator |4 oth | |
700 | 1 | |a Hobbs, Charlotte V |e investigator |4 oth | |
700 | 1 | |a Martin, Lora |e investigator |4 oth | |
700 | 1 | |a Malloch, Lacy |e investigator |4 oth | |
700 | 1 | |a Inagaki, Kengo |e investigator |4 oth | |
700 | 1 | |a Dhanrajani, Anita |e investigator |4 oth | |
700 | 1 | |a Schuster, Jennifer E |e investigator |4 oth | |
700 | 1 | |a Kietzman, Abigail |e investigator |4 oth | |
700 | 1 | |a Hill, Shannon |e investigator |4 oth | |
700 | 1 | |a Spinella, Philip C |e investigator |4 oth | |
700 | 1 | |a Cullimore, Melissa L |e investigator |4 oth | |
700 | 1 | |a McCulloh, Russell J |e investigator |4 oth | |
700 | 1 | |a Clouser, Katharine N |e investigator |4 oth | |
700 | 1 | |a Gertz, Shira J |e investigator |4 oth | |
700 | 1 | |a Kleinman, Lawrence C |e investigator |4 oth | |
700 | 1 | |a Li, Simon |e investigator |4 oth | |
700 | 1 | |a Horwitz, Steven M |e investigator |4 oth | |
700 | 1 | |a Ratner, Adam J |e investigator |4 oth | |
700 | 1 | |a Dapul, Heda |e investigator |4 oth | |
700 | 1 | |a Soma, Vijaya L |e investigator |4 oth | |
700 | 1 | |a Keenaghan, Michael A |e investigator |4 oth | |
700 | 1 | |a Singh, Aalok R |e investigator |4 oth | |
700 | 1 | |a Harwayne-Gidansky, Ilana |e investigator |4 oth | |
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700 | 1 | |a Shein, Steven L |e investigator |4 oth | |
700 | 1 | |a Lansell, Amanda N |e investigator |4 oth | |
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700 | 1 | |a Fink, Ericka L |e investigator |4 oth | |
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