Impact on quality of life in multiple sclerosis patients : Which urinary symptoms are to blame?
Copyright © 2022 Elsevier Masson SAS. All rights reserved..
AIM: To evaluate the correlation between the Expanded Disability Status Scale (EDSS) in multiple sclerosis (MS) subjects, and the severity of lower urinary tract symptoms (LUTS), the bother caused by these symptoms and subjects' quality of life (QoL).
MATERIAL AND METHODS: This cross-sectional study included 50 subjects with persistent LUTS secondary to MS who were recruited from the registry of a national NGO, between October 2017 and November 2019. Subjects with a history of any disease besides MS that could otherwise explain the presence of LUTS, as well as those with other neurological conditions were excluded. Information including MS duration, subjects' EDSS, voiding and storage LUTS, voiding symptoms' subscore of the International Prostate Symptom Score (IPSS-V), Overactive Bladder Symptom Scores (OABSS), Urinary Bothersome Questionnaire in Multiple Sclerosis (UBQMS), and urologic QoL (SF-Qualiveen) was gathered. Correlations between these scores were assessed using Spearman's bivariate correlations. Wilcoxon's signed rank test was used to evaluate the difference of impact between voiding and storage LUTS on bother of subjects.
RESULTS: The median disease duration was 7±5.8years and the predominant lower urinary symptom was urgency (82%). Median OABSS and IPSS-V were respectively 8±3.8 and 8±3. Subjects were significantly more bothered from storage than voiding symptoms (2 vs. 1.6; P=0.03), and their QoL was directly affected by storage LUTS. Urgency urinary incontinence had the highest positive correlation with SFQ (r=0.542; P<0.01). MS duration and urologic QoL measured by SF-Q were negatively correlated (r=-0.345; P=0.01).
CONCLUSION: In MS patients with LUTS, urologic QoL is mainly affected by storage urinary symptoms. Physicians should use a holistic approach to reduce the risk of complications in these patients, by controlling both voiding and storage symptoms, in particular urgency urinary incontinence that mostly affects patient's QoL.
LEVEL OF EVIDENCE: 3:.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie - 32(2022), 10 vom: 15. Sept., Seite 711-716 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ziadeh, T [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 30.08.2022 Date Revised 30.08.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.purol.2022.05.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM342365401 |
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| 100 | 1 | |a Ziadeh, T |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact on quality of life in multiple sclerosis patients |b Which urinary symptoms are to blame? |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 30.08.2022 | ||
| 500 | |a Date Revised 30.08.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a AIM: To evaluate the correlation between the Expanded Disability Status Scale (EDSS) in multiple sclerosis (MS) subjects, and the severity of lower urinary tract symptoms (LUTS), the bother caused by these symptoms and subjects' quality of life (QoL) | ||
| 520 | |a MATERIAL AND METHODS: This cross-sectional study included 50 subjects with persistent LUTS secondary to MS who were recruited from the registry of a national NGO, between October 2017 and November 2019. Subjects with a history of any disease besides MS that could otherwise explain the presence of LUTS, as well as those with other neurological conditions were excluded. Information including MS duration, subjects' EDSS, voiding and storage LUTS, voiding symptoms' subscore of the International Prostate Symptom Score (IPSS-V), Overactive Bladder Symptom Scores (OABSS), Urinary Bothersome Questionnaire in Multiple Sclerosis (UBQMS), and urologic QoL (SF-Qualiveen) was gathered. Correlations between these scores were assessed using Spearman's bivariate correlations. Wilcoxon's signed rank test was used to evaluate the difference of impact between voiding and storage LUTS on bother of subjects | ||
| 520 | |a RESULTS: The median disease duration was 7±5.8years and the predominant lower urinary symptom was urgency (82%). Median OABSS and IPSS-V were respectively 8±3.8 and 8±3. Subjects were significantly more bothered from storage than voiding symptoms (2 vs. 1.6; P=0.03), and their QoL was directly affected by storage LUTS. Urgency urinary incontinence had the highest positive correlation with SFQ (r=0.542; P<0.01). MS duration and urologic QoL measured by SF-Q were negatively correlated (r=-0.345; P=0.01) | ||
| 520 | |a CONCLUSION: In MS patients with LUTS, urologic QoL is mainly affected by storage urinary symptoms. Physicians should use a holistic approach to reduce the risk of complications in these patients, by controlling both voiding and storage symptoms, in particular urgency urinary incontinence that mostly affects patient's QoL | ||
| 520 | |a LEVEL OF EVIDENCE: 3: | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Lower urinary tract symptoms | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 4 | |a Quality of life | |
| 650 | 4 | |a Qualité de vie | |
| 650 | 4 | |a Sclérose en plaques | |
| 650 | 4 | |a Troubles du bas appareil urinaire | |
| 700 | 1 | |a Mjaess, G |e verfasserin |4 aut | |
| 700 | 1 | |a El Helou, J |e verfasserin |4 aut | |
| 700 | 1 | |a Zalaket, J |e verfasserin |4 aut | |
| 700 | 1 | |a Mouawad, C |e verfasserin |4 aut | |
| 700 | 1 | |a Azar, C |e verfasserin |4 aut | |
| 700 | 1 | |a Abboud, H |e verfasserin |4 aut | |
| 700 | 1 | |a Koussa, S |e verfasserin |4 aut | |
| 700 | 1 | |a Nemr, E |e verfasserin |4 aut | |
| 700 | 1 | |a El Helou, E |e verfasserin |4 aut | |
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