Synthesis of Thiophene/Furan-Artemisinin Hybrid Molecules
© 2022 Wiley-VHCA AG, Zurich, Switzerland..
Natural products with semi-synthetic molecules displays higher biological activities, and creates new biological properties for the treatment of diseases. Although, natural products like artemisinin have been used as a traditional medicine over thousands of years, structure and biological properties of many natural products were investigated in the 20th century. Design and synthesis of new biologically active compounds including natural products have very critical roles to find novel drug candidates. Herein, novel thiophene/furan bridge artemisinin derivatives were synthesized by starting from artemisinin. Firstly, benzothiophene derivatives are synthesized, then Steglich esterification reactions give the new artemisinin hybrid molecules with moderate to high yields.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Chemistry & biodiversity - 19(2022), 8 vom: 17. Aug., Seite e202200144 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ozok-Arici, Omruye [VerfasserIn] |
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| Links: |
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| Themen: |
Artemisinin |
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| Anmerkungen: |
Date Completed 19.08.2022 Date Revised 19.08.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/cbdv.202200144 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Natural products with semi-synthetic molecules displays higher biological activities, and creates new biological properties for the treatment of diseases. Although, natural products like artemisinin have been used as a traditional medicine over thousands of years, structure and biological properties of many natural products were investigated in the 20th century. Design and synthesis of new biologically active compounds including natural products have very critical roles to find novel drug candidates. Herein, novel thiophene/furan bridge artemisinin derivatives were synthesized by starting from artemisinin. Firstly, benzothiophene derivatives are synthesized, then Steglich esterification reactions give the new artemisinin hybrid molecules with moderate to high yields | ||
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