The antiviral targeting potential of viroporins
Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far only used in Influenza A with the drugs amantadine and rimantadine. In this review, we seek to utilize the inhibition by amantadine of the viroporin Protein E in SARS-CoV-2 in an attempt to treat COVID-19 in its early stages. We are executing a double-blinded placebo-controlled trial based on promising in vivo and in vitro work as a stepping-stone for establishing a therapeutic antiviral regime: blocking of viroporins.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:184 |
|---|---|
| Enthalten in: |
Ugeskrift for laeger - 184(2022), 24 vom: 13. Juni |
| Sprache: |
Dänisch |
|---|
| Beteiligte Personen: |
Sund, John D [VerfasserIn] |
|---|
| Themen: |
Amantadine |
|---|
| Anmerkungen: |
Date Completed 16.06.2022 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM342245392 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM342245392 | ||
| 003 | DE-627 | ||
| 005 | 20231226013647.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||dan c | ||
| 028 | 5 | 2 | |a pubmed24n1140.xml |
| 035 | |a (DE-627)NLM342245392 | ||
| 035 | |a (NLM)35703076 | ||
| 035 | |a (PII)V02220103 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a dan | ||
| 100 | 1 | |a Sund, John D |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The antiviral targeting potential of viroporins |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.06.2022 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far only used in Influenza A with the drugs amantadine and rimantadine. In this review, we seek to utilize the inhibition by amantadine of the viroporin Protein E in SARS-CoV-2 in an attempt to treat COVID-19 in its early stages. We are executing a double-blinded placebo-controlled trial based on promising in vivo and in vitro work as a stepping-stone for establishing a therapeutic antiviral regime: blocking of viroporins | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 650 | 7 | |a Viroporin Proteins |2 NLM | |
| 650 | 7 | |a Amantadine |2 NLM | |
| 650 | 7 | |a BF4C9Z1J53 |2 NLM | |
| 700 | 1 | |a Bollerup, Signe |e verfasserin |4 aut | |
| 700 | 1 | |a Glamann, Jekob B |e verfasserin |4 aut | |
| 700 | 1 | |a Vinten, Caroline An |e verfasserin |4 aut | |
| 700 | 1 | |a Jensen, Louise R |e verfasserin |4 aut | |
| 700 | 1 | |a Toft-Bethelsen, Trine L |e verfasserin |4 aut | |
| 700 | 1 | |a Bentzen, Bo H |e verfasserin |4 aut | |
| 700 | 1 | |a Kledal, Thomas N |e verfasserin |4 aut | |
| 700 | 1 | |a Weis, Nina |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenkilde, Mette |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Ugeskrift for laeger |d 1945 |g 184(2022), 24 vom: 13. Juni |w (DE-627)NLM000011185 |x 1603-6824 |7 nnns |
| 773 | 1 | 8 | |g volume:184 |g year:2022 |g number:24 |g day:13 |g month:06 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 184 |j 2022 |e 24 |b 13 |c 06 | ||