Supramolecular encapsulation of nanocrystalline Schiff bases into β-cyclodextrin for multifold enrichment of bio-potency
Copyright © 2022 Elsevier Ltd. All rights reserved..
We report the solvent-free green synthesis of two Schiff bases, (E)-2-((2-hydroxy-3-methoxybenzylidene)amino)-4-methylphenol (SL1) and (E)-2-((2-hydroxybenzylidene) amino)-4-methylphenol (SL2), and their inclusion complexes with β-cyclodextrin (β-CD). The encapsulation phenomenon, structural characteristics and hydrolytic stabilities of the SL1, SL2 and their inclusion complexes are determined with a suite of spectroscopic, analytical and crystallographic analyses. Dose and time-dependent cytotoxicity study of SL1-β-CD and SL2-β-CD against two breast cancer cell lines, Michigan Cancer Foundation-7 (MCF-7) and metastatic mammary adenocarcinoma1 (MDA-MB-231), exhibit excellent inhibitory activity with significant non-cytotoxic concentrations and ensure a multifold elevation of bio-potency than the parent Schiff base compounds. The Annexin-V assay determines the efficacy of these inclusion complexes to trigger apoptosis, suggesting that SL2-β-CD possesses better efficacy as an anti-cancer drug. To the best of our knowledge, we, for the first time, report the inclusion of nanocrystalline Schiff bases into β-CD for multifold enrichment of bio-potency.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:291 |
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| Enthalten in: |
Carbohydrate polymers - 291(2022) vom: 01. Sept., Seite 119614 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mahato, Rajani Kanta [VerfasserIn] |
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| Links: |
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| Themen: |
β-Cyclodextrin |
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| Anmerkungen: |
Date Completed 15.06.2022 Date Revised 15.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.carbpol.2022.119614 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM342199854 |
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| 520 | |a Copyright © 2022 Elsevier Ltd. All rights reserved. | ||
| 520 | |a We report the solvent-free green synthesis of two Schiff bases, (E)-2-((2-hydroxy-3-methoxybenzylidene)amino)-4-methylphenol (SL1) and (E)-2-((2-hydroxybenzylidene) amino)-4-methylphenol (SL2), and their inclusion complexes with β-cyclodextrin (β-CD). The encapsulation phenomenon, structural characteristics and hydrolytic stabilities of the SL1, SL2 and their inclusion complexes are determined with a suite of spectroscopic, analytical and crystallographic analyses. Dose and time-dependent cytotoxicity study of SL1-β-CD and SL2-β-CD against two breast cancer cell lines, Michigan Cancer Foundation-7 (MCF-7) and metastatic mammary adenocarcinoma1 (MDA-MB-231), exhibit excellent inhibitory activity with significant non-cytotoxic concentrations and ensure a multifold elevation of bio-potency than the parent Schiff base compounds. The Annexin-V assay determines the efficacy of these inclusion complexes to trigger apoptosis, suggesting that SL2-β-CD possesses better efficacy as an anti-cancer drug. To the best of our knowledge, we, for the first time, report the inclusion of nanocrystalline Schiff bases into β-CD for multifold enrichment of bio-potency | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antiproliferative activity | |
| 650 | 4 | |a Encapsulation | |
| 650 | 4 | |a Nano-crystal | |
| 650 | 4 | |a Schiff base | |
| 650 | 4 | |a X-ray crystallography | |
| 650 | 4 | |a β-Cyclodextrin | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 650 | 7 | |a Schiff Bases |2 NLM | |
| 650 | 7 | |a beta-Cyclodextrins |2 NLM | |
| 700 | 1 | |a Debnath, Ananya |e verfasserin |4 aut | |
| 700 | 1 | |a Das, Ajit |e verfasserin |4 aut | |
| 700 | 1 | |a Sarkar, Debanjan |e verfasserin |4 aut | |
| 700 | 1 | |a Bhattacharyya, Sankar |e verfasserin |4 aut | |
| 700 | 1 | |a Biswas, Bhaskar |e verfasserin |4 aut | |
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