Buffet-style Cu(II) for enhance disulfiram-based cancer therapy
Copyright © 2022 Elsevier Inc. All rights reserved..
Studies have shown that disulfiram (DSF) can combine with Cu2+ to form bis(N, N-diethyldithiocarbamate) copper(II) complex (CuET) as antitumor drugs. However, there is insufficient endogenous Cu2+ dose to eradicate cancer cells selectively. Inspired by the buffet, we use Cu2+ doped hollow zeolitic imidazolate framework nanoparticles (HZIFCu) as the carrier and equipped with DSF and indocyanine green (ICG) and targeted by folic acid (FA) (D&IHZIFCu-FA) to enhance DSF-based cancer therapy. D&I@HZIFCu-FA could effectively supply Cu2+ by a buffet-style, assisting the "DSF-to-CuET" transformation in the tumor. Additionally, self-supply Cu2+ could convert H2O2 into ·OH by triggering a Fenton-like reaction for chemo-dynamic therapy, and ICG achieves photothermal therapy for tumors under laser irradiation. This work provides a buffet-style for Cu2+ to make DSF a strong candidate for cancer treatment by combining chemotherapy, chemo-dynamic therapy, and photothermal therapy and inspires more research about its applications in tumor therapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:624 |
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| Enthalten in: |
Journal of colloid and interface science - 624(2022) vom: 15. Okt., Seite 734-746 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Liping [VerfasserIn] |
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| Links: |
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| Themen: |
789U1901C5 |
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| Anmerkungen: |
Date Completed 21.06.2022 Date Revised 21.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jcis.2022.06.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM342183788 |
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| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a Studies have shown that disulfiram (DSF) can combine with Cu2+ to form bis(N, N-diethyldithiocarbamate) copper(II) complex (CuET) as antitumor drugs. However, there is insufficient endogenous Cu2+ dose to eradicate cancer cells selectively. Inspired by the buffet, we use Cu2+ doped hollow zeolitic imidazolate framework nanoparticles (HZIFCu) as the carrier and equipped with DSF and indocyanine green (ICG) and targeted by folic acid (FA) (D&IHZIFCu-FA) to enhance DSF-based cancer therapy. D&I@HZIFCu-FA could effectively supply Cu2+ by a buffet-style, assisting the "DSF-to-CuET" transformation in the tumor. Additionally, self-supply Cu2+ could convert H2O2 into ·OH by triggering a Fenton-like reaction for chemo-dynamic therapy, and ICG achieves photothermal therapy for tumors under laser irradiation. This work provides a buffet-style for Cu2+ to make DSF a strong candidate for cancer treatment by combining chemotherapy, chemo-dynamic therapy, and photothermal therapy and inspires more research about its applications in tumor therapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chemo-dynamic therapy | |
| 650 | 4 | |a Chemotherapy | |
| 650 | 4 | |a Disulfiram | |
| 650 | 4 | |a Photothermal therapy | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 650 | 7 | |a Copper |2 NLM | |
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| 700 | 1 | |a Wang, Xiaoxia |e verfasserin |4 aut | |
| 700 | 1 | |a Lou, Han |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Mingxia |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Xinghan |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Jiamin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jingqi |e verfasserin |4 aut | |
| 700 | 1 | |a Guan, Xiuwen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wentong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Weifen |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Jinlong |e verfasserin |4 aut | |
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