Diet and gastric cancer risk : an umbrella review of systematic reviews and meta-analyses of prospective cohort studies
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
BACKGROUND: Several systematic reviews and meta-analyses evaluated the associations between dietary factors and the incidence of gastric cancer (GC).
OBJECTIVES: To evaluate the strength and validity of existing evidence, we conducted an umbrella review of published systematic reviews and meta-analyses that investigated the association between diets and GC incidence.
METHODS: We searched the PubMed, Embase, and Cochrane databases for systematic reviews and meta-analyses of prospective cohort studies investigating the association between dietary factors and GC risk. For each association, we recalculated the adjusted summary estimates with their 95% confidence interval (CI) and 95% prediction interval (PI) using a random-effects model. We used the I2 statistic and Egger's test to assess heterogeneity and small-study effects, respectively. We also assessed the methodological quality of each study and the quality of evidence.
RESULTS: Finally, we identified 16 meta-analyses that described 57 associations in this umbrella review. Of the 57 associations, eight were statistically significant using random-effects, thirteen demonstrated substantial heterogeneity between studies (I2 > 50%), and three found small-study effects. The methodological quality of meta-analyses was classified as critically low for two (13%), low for thirteen (81%), and only one (6%) was rated as high confidence. Quality of evidence was rated high for a positive association for GC incidence with a higher intake of total alcohol (RR = 1.19, 95% CI 1.06-1.34) and moderate-quality evidence to support that increased processed meat consumption can increase GC incidence. Three associations (total fruit, vitamin E, and carotenoids) were determined to be supported by low-quality evidence, and two (pickled vegetables/foods and citrus fruit) were supported by very low-quality.
CONCLUSIONS: Our findings support the dietary recommendations for preventative GC, emphasizing lower intake of alcohol and foods preserved by salting. New evidence suggests a possible role for total fruit, citrus fruit, carotenoids, and vitamin E. More research is needed on diets with lower quality evidence.
REGISTRATION NUMBER: CRD42021255115.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:148 |
---|---|
Enthalten in: |
Journal of cancer research and clinical oncology - 148(2022), 8 vom: 28. Aug., Seite 1855-1868 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Liu, Shu-Jun [VerfasserIn] |
---|
Links: |
---|
Themen: |
1406-18-4 |
---|
Anmerkungen: |
Date Completed 20.07.2022 Date Revised 21.07.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1007/s00432-022-04005-1 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM34217553X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM34217553X | ||
003 | DE-627 | ||
005 | 20231226013506.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00432-022-04005-1 |2 doi | |
028 | 5 | 2 | |a pubmed24n1140.xml |
035 | |a (DE-627)NLM34217553X | ||
035 | |a (NLM)35695929 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Liu, Shu-Jun |e verfasserin |4 aut | |
245 | 1 | 0 | |a Diet and gastric cancer risk |b an umbrella review of systematic reviews and meta-analyses of prospective cohort studies |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 20.07.2022 | ||
500 | |a Date Revised 21.07.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
520 | |a BACKGROUND: Several systematic reviews and meta-analyses evaluated the associations between dietary factors and the incidence of gastric cancer (GC) | ||
520 | |a OBJECTIVES: To evaluate the strength and validity of existing evidence, we conducted an umbrella review of published systematic reviews and meta-analyses that investigated the association between diets and GC incidence | ||
520 | |a METHODS: We searched the PubMed, Embase, and Cochrane databases for systematic reviews and meta-analyses of prospective cohort studies investigating the association between dietary factors and GC risk. For each association, we recalculated the adjusted summary estimates with their 95% confidence interval (CI) and 95% prediction interval (PI) using a random-effects model. We used the I2 statistic and Egger's test to assess heterogeneity and small-study effects, respectively. We also assessed the methodological quality of each study and the quality of evidence | ||
520 | |a RESULTS: Finally, we identified 16 meta-analyses that described 57 associations in this umbrella review. Of the 57 associations, eight were statistically significant using random-effects, thirteen demonstrated substantial heterogeneity between studies (I2 > 50%), and three found small-study effects. The methodological quality of meta-analyses was classified as critically low for two (13%), low for thirteen (81%), and only one (6%) was rated as high confidence. Quality of evidence was rated high for a positive association for GC incidence with a higher intake of total alcohol (RR = 1.19, 95% CI 1.06-1.34) and moderate-quality evidence to support that increased processed meat consumption can increase GC incidence. Three associations (total fruit, vitamin E, and carotenoids) were determined to be supported by low-quality evidence, and two (pickled vegetables/foods and citrus fruit) were supported by very low-quality | ||
520 | |a CONCLUSIONS: Our findings support the dietary recommendations for preventative GC, emphasizing lower intake of alcohol and foods preserved by salting. New evidence suggests a possible role for total fruit, citrus fruit, carotenoids, and vitamin E. More research is needed on diets with lower quality evidence | ||
520 | |a REGISTRATION NUMBER: CRD42021255115 | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Diet | |
650 | 4 | |a Evidence | |
650 | 4 | |a Gastric cancer | |
650 | 4 | |a Meta-analysis | |
650 | 4 | |a Umbrella review | |
650 | 7 | |a Vitamin E |2 NLM | |
650 | 7 | |a 1406-18-4 |2 NLM | |
650 | 7 | |a Carotenoids |2 NLM | |
650 | 7 | |a 36-88-4 |2 NLM | |
700 | 1 | |a Huang, Pi-Di |e verfasserin |4 aut | |
700 | 1 | |a Xu, Jia-Min |e verfasserin |4 aut | |
700 | 1 | |a Li, Qian |e verfasserin |4 aut | |
700 | 1 | |a Xie, Jian-Hui |e verfasserin |4 aut | |
700 | 1 | |a Wu, Wen-Zhen |e verfasserin |4 aut | |
700 | 1 | |a Wang, Chen-Tong |e verfasserin |4 aut | |
700 | 1 | |a Yang, Xiao-Bo |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of cancer research and clinical oncology |d 1981 |g 148(2022), 8 vom: 28. Aug., Seite 1855-1868 |w (DE-627)NLM000394610 |x 1432-1335 |7 nnns |
773 | 1 | 8 | |g volume:148 |g year:2022 |g number:8 |g day:28 |g month:08 |g pages:1855-1868 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00432-022-04005-1 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 148 |j 2022 |e 8 |b 28 |c 08 |h 1855-1868 |