Cabbage juice supplementation abrogates Lead acetate-induced haematological and haemorheological imbalances in male Wistar rat
Lead is a hazardous naturally found heavy metal that has been reported to induce haematological alterations. Whether cabbage, a commonly consumed vegetable rich in antioxidants and anticancer compounds, can mitigate these alterations remains unknown. This study investigated the protective effect of cabbage juice against Lead-induced haematological changes. Twenty (20) male Wistar rats were randomly selected into four groups (n = 5) and given distilled water (1 ml/100 g b.wt), Lead acetate (25 mg/kg b.wt), Cabbage juice (1 ml/100 g b.wt), and Lead acetate with Cabbage juice. All treatments were given orally for 28 days. Lead exposure induces normocytic normochromic anemia with substantial leukocytosis, lymphocytopenia, and hyperfibrinogenemia. Lead-intoxicated animals had significantly higher haemolysis and prolonged clotting times. However, cabbage juice reverses these adverse haematological and haemorheological changes induced by Lead acetate. Conclusively, cabbage juice demonstrated antioxidant, anti-inflammatory, anti-thrombotic, and immunomodulatory properties, as well as the ability to protect the red blood cell membrane from damage caused by Lead-induced osmotic stress.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
International journal of environmental health research - 33(2023), 12 vom: 14. Dez., Seite 1331-1340 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Asiwe, Jerome Ndudi [VerfasserIn] |
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| Links: |
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| Themen: |
2P299V784P |
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| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/09603123.2022.2086973 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM342087614 |
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| 245 | 1 | 0 | |a Cabbage juice supplementation abrogates Lead acetate-induced haematological and haemorheological imbalances in male Wistar rat |
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| 520 | |a Lead is a hazardous naturally found heavy metal that has been reported to induce haematological alterations. Whether cabbage, a commonly consumed vegetable rich in antioxidants and anticancer compounds, can mitigate these alterations remains unknown. This study investigated the protective effect of cabbage juice against Lead-induced haematological changes. Twenty (20) male Wistar rats were randomly selected into four groups (n = 5) and given distilled water (1 ml/100 g b.wt), Lead acetate (25 mg/kg b.wt), Cabbage juice (1 ml/100 g b.wt), and Lead acetate with Cabbage juice. All treatments were given orally for 28 days. Lead exposure induces normocytic normochromic anemia with substantial leukocytosis, lymphocytopenia, and hyperfibrinogenemia. Lead-intoxicated animals had significantly higher haemolysis and prolonged clotting times. However, cabbage juice reverses these adverse haematological and haemorheological changes induced by Lead acetate. Conclusively, cabbage juice demonstrated antioxidant, anti-inflammatory, anti-thrombotic, and immunomodulatory properties, as well as the ability to protect the red blood cell membrane from damage caused by Lead-induced osmotic stress | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Haematocytopenia | |
| 650 | 4 | |a Lead acetate | |
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| 650 | 4 | |a haemorheology | |
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| 700 | 1 | |a Kolawole, Tolunigba Abisola |e verfasserin |4 aut | |
| 700 | 1 | |a Buduburisi, Buduchim Rejoice |e verfasserin |4 aut | |
| 700 | 1 | |a Adebayo, Olusegun Gafar |e verfasserin |4 aut | |
| 700 | 1 | |a Onuoha, Ogechukwu Grace |e verfasserin |4 aut | |
| 700 | 1 | |a Inegbenehi, Saviour |e verfasserin |4 aut | |
| 700 | 1 | |a Ademilusi, Emmanuel Oluwaseun |e verfasserin |4 aut | |
| 700 | 1 | |a Dapper, Datonye Victor |e verfasserin |4 aut | |
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