Clinical course and mortality in older patients with COVID-19 : a cluster-based study in Hong Kong
INTRODUCTION: Compared with previous waves of the coronavirus disease 2019 (COVID-19) pandemic in Hong Kong, the third wave involved a greater number of frail older patients. Because local healthcare policy required hospitalisation for all older adults with COVID-19, we aimed to investigate the clinical course and outcomes in such patients.
METHODS: This retrospective observational study included all patients aged ≥65 years who were admitted to Tuen Mun Hospital for management of COVID-19 between 1 July 2020 and 31 August 2020. We reviewed baseline characteristics, clinical presentation, laboratory results, complications, and outcomes. We also investigated the associations of age and Clinical Frailty Scale (CFS) score with in-patient mortality.
RESULTS: In total, 101 patients were included (median age, 73 years); 52.5% were men and 85% had at least co-morbid chronic disease. The most common symptoms were fever (80.2%) and cough (63.4%). Fifty-two patients (51.5%) developed hypoxia, generally on day 8 (interquartile range, 5-11) after symptom onset. Of the 16 patients who required intensive care unit support, 13 required mechanical ventilation. The overall mortality rate was 16.8%. Patients aged 65-69, 70-79, 80-89, and ≥90 years had mortality rates of 9.1%, 10%, 30%, and 25%, respectively. Patients with CFS scores of 1-2, 3-4, 5-6, and ≥7 had mortality rates of 5.7%, 14.7%, 23.5%, and 40%, respectively. A linear relationship was confirmed between the two mortality trends.
CONCLUSION: Clinical deterioration was common in older patients with COVID-19; their overall mortality rate was 16.8%. Mortality increased linearly with both age and CFS score.
| Errataetall: |
CommentIn: Hong Kong Med J. 2023 Apr;29(2):181. - PMID 37055194 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
|---|---|
| Enthalten in: |
Hong Kong medical journal = Xianggang yi xue za zhi - 28(2022), 3 vom: 01. Juni, Seite 215-222 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Tam, E M Y Y [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Aged |
|---|
| Anmerkungen: |
Date Completed 30.06.2022 Date Revised 06.06.2023 published: Print-Electronic CommentIn: Hong Kong Med J. 2023 Apr;29(2):181. - PMID 37055194 Citation Status MEDLINE |
|---|
| doi: |
10.12809/hkmj219367 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM342081691 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM342081691 | ||
| 003 | DE-627 | ||
| 005 | 20231226013245.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.12809/hkmj219367 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1140.xml |
| 035 | |a (DE-627)NLM342081691 | ||
| 035 | |a (NLM)35686472 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Tam, E M Y Y |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical course and mortality in older patients with COVID-19 |b a cluster-based study in Hong Kong |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.06.2022 | ||
| 500 | |a Date Revised 06.06.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Hong Kong Med J. 2023 Apr;29(2):181. - PMID 37055194 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Compared with previous waves of the coronavirus disease 2019 (COVID-19) pandemic in Hong Kong, the third wave involved a greater number of frail older patients. Because local healthcare policy required hospitalisation for all older adults with COVID-19, we aimed to investigate the clinical course and outcomes in such patients | ||
| 520 | |a METHODS: This retrospective observational study included all patients aged ≥65 years who were admitted to Tuen Mun Hospital for management of COVID-19 between 1 July 2020 and 31 August 2020. We reviewed baseline characteristics, clinical presentation, laboratory results, complications, and outcomes. We also investigated the associations of age and Clinical Frailty Scale (CFS) score with in-patient mortality | ||
| 520 | |a RESULTS: In total, 101 patients were included (median age, 73 years); 52.5% were men and 85% had at least co-morbid chronic disease. The most common symptoms were fever (80.2%) and cough (63.4%). Fifty-two patients (51.5%) developed hypoxia, generally on day 8 (interquartile range, 5-11) after symptom onset. Of the 16 patients who required intensive care unit support, 13 required mechanical ventilation. The overall mortality rate was 16.8%. Patients aged 65-69, 70-79, 80-89, and ≥90 years had mortality rates of 9.1%, 10%, 30%, and 25%, respectively. Patients with CFS scores of 1-2, 3-4, 5-6, and ≥7 had mortality rates of 5.7%, 14.7%, 23.5%, and 40%, respectively. A linear relationship was confirmed between the two mortality trends | ||
| 520 | |a CONCLUSION: Clinical deterioration was common in older patients with COVID-19; their overall mortality rate was 16.8%. Mortality increased linearly with both age and CFS score | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Frail elderly | |
| 650 | 4 | |a Frailty | |
| 650 | 4 | |a Hong Kong | |
| 650 | 4 | |a Hospital mortality | |
| 650 | 4 | |a Hypoxia | |
| 700 | 1 | |a Kwan, Y K |e verfasserin |4 aut | |
| 700 | 1 | |a Ng, Y Y |e verfasserin |4 aut | |
| 700 | 1 | |a Yam, P W |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Hong Kong medical journal = Xianggang yi xue za zhi |d 1997 |g 28(2022), 3 vom: 01. Juni, Seite 215-222 |w (DE-627)NLM094541337 |x 1024-2708 |7 nnns |
| 773 | 1 | 8 | |g volume:28 |g year:2022 |g number:3 |g day:01 |g month:06 |g pages:215-222 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.12809/hkmj219367 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 28 |j 2022 |e 3 |b 01 |c 06 |h 215-222 | ||