Solid cancer patients achieve adequate immunogenicity and low rate of severe adverse events after SARS-CoV-2 vaccination
Background: SARS-CoV-2 vaccination in cancer patients is crucial to prevent severe COVID-19 disease course. Methods: This study assessed immunogenicity of cancer patients on active treatment receiving mRNA-based SARS-CoV-2 vaccine by detection of anti-SARS-CoV-2 S1 IgG antibodies in serum, before, after the first and second doses and 3 months after a complete primary course of vaccination. Results were compared with healthy controls. Results: Of 112 patients, the seroconversion rate was 96%. A significant reduction in antibody levels was observed 3 months after vaccination in patients receiving immune checkpoint inhibitors versus control participants (p < 0.001). Adverse events were mostly mild. Conclusion: Immunogenicity after mRNA-based vaccine in cancer patients is adequate but influenced by the type of anticancer therapy. Antibody levels decline after 3 months, and thus a third vaccination is warranted.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
---|---|
Enthalten in: |
Future oncology (London, England) - 18(2022), 23 vom: 09. Juli, Seite 2537-2550 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Janzic, Urska [VerfasserIn] |
---|
Links: |
---|
Themen: |
Antibodies, Viral |
---|
Anmerkungen: |
Date Completed 13.07.2022 Date Revised 16.07.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.2217/fon-2022-0148 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM342003631 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM342003631 | ||
003 | DE-627 | ||
005 | 20231226013056.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.2217/fon-2022-0148 |2 doi | |
028 | 5 | 2 | |a pubmed24n1139.xml |
035 | |a (DE-627)NLM342003631 | ||
035 | |a (NLM)35678621 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Janzic, Urska |e verfasserin |4 aut | |
245 | 1 | 0 | |a Solid cancer patients achieve adequate immunogenicity and low rate of severe adverse events after SARS-CoV-2 vaccination |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 13.07.2022 | ||
500 | |a Date Revised 16.07.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Background: SARS-CoV-2 vaccination in cancer patients is crucial to prevent severe COVID-19 disease course. Methods: This study assessed immunogenicity of cancer patients on active treatment receiving mRNA-based SARS-CoV-2 vaccine by detection of anti-SARS-CoV-2 S1 IgG antibodies in serum, before, after the first and second doses and 3 months after a complete primary course of vaccination. Results were compared with healthy controls. Results: Of 112 patients, the seroconversion rate was 96%. A significant reduction in antibody levels was observed 3 months after vaccination in patients receiving immune checkpoint inhibitors versus control participants (p < 0.001). Adverse events were mostly mild. Conclusion: Immunogenicity after mRNA-based vaccine in cancer patients is adequate but influenced by the type of anticancer therapy. Antibody levels decline after 3 months, and thus a third vaccination is warranted | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a anticancer treatment | |
650 | 4 | |a immunogenicity | |
650 | 4 | |a mRNA-based vaccination | |
650 | 4 | |a seroconversion | |
650 | 4 | |a solid cancer | |
650 | 7 | |a Antibodies, Viral |2 NLM | |
650 | 7 | |a COVID-19 Vaccines |2 NLM | |
650 | 7 | |a Immunoglobulin G |2 NLM | |
700 | 1 | |a Bidovec-Stojkovic, Urska |e verfasserin |4 aut | |
700 | 1 | |a Mohorcic, Katja |e verfasserin |4 aut | |
700 | 1 | |a Mrak, Loredana |e verfasserin |4 aut | |
700 | 1 | |a Dovnik, Nina Fokter |e verfasserin |4 aut | |
700 | 1 | |a Ivanovic, Marija |e verfasserin |4 aut | |
700 | 1 | |a Ravnik, Maja |e verfasserin |4 aut | |
700 | 1 | |a Caks, Marina |e verfasserin |4 aut | |
700 | 1 | |a Skof, Erik |e verfasserin |4 aut | |
700 | 1 | |a Debeljak, Jerneja |e verfasserin |4 aut | |
700 | 1 | |a Korosec, Peter |e verfasserin |4 aut | |
700 | 1 | |a Rijavec, Matija |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Future oncology (London, England) |d 2005 |g 18(2022), 23 vom: 09. Juli, Seite 2537-2550 |w (DE-627)NLM161450725 |x 1744-8301 |7 nnns |
773 | 1 | 8 | |g volume:18 |g year:2022 |g number:23 |g day:09 |g month:07 |g pages:2537-2550 |
856 | 4 | 0 | |u http://dx.doi.org/10.2217/fon-2022-0148 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 18 |j 2022 |e 23 |b 09 |c 07 |h 2537-2550 |