Towards in vivo photomediated delivery of anticancer peptides : Insights from pharmacokinetic and -dynamic data
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved..
An in vivo study of a photoswitchable cytotoxic peptide LMB040 has been undertaken on a chemically induced hepatocellular carcinoma model in immunocompetent rats. We analysed the pharmacokinetic profile of the less toxic photoform ("ring-closed" dithienylethene) of the compound in tumors, plasma, and healthy liver. Accordingly, the peptide can reach a tumor concentration sufficiently high to exert a cytotoxic effect upon photoconversion into the more active ("ring-open") photoform. Tissue morphology, histology, redox state of the liver, and hepatic biochemical parameters in blood serum were analysed upon treatment with (i) the less active photoform, (ii) the in vivo light-activated alternative photoform, and (iii) compared with a reference chemotherapeutic 5-fluorouracil. We found that application of the less toxic form followed by a delayed in vivo photoconversion into the more toxic ring-open form of LMB040 led to a higher overall survival of the animals, and signs of enhanced immune response were observed compared to the untreated animals.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:233 |
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| Enthalten in: |
Journal of photochemistry and photobiology. B, Biology - 233(2022) vom: 15. Aug., Seite 112479 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Komarov, Igor V [VerfasserIn] |
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| Links: |
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| Themen: |
Anticancer peptides |
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| Anmerkungen: |
Date Completed 12.07.2022 Date Revised 12.07.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jphotobiol.2022.112479 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Komarov, Igor V |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Towards in vivo photomediated delivery of anticancer peptides |b Insights from pharmacokinetic and -dynamic data |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a An in vivo study of a photoswitchable cytotoxic peptide LMB040 has been undertaken on a chemically induced hepatocellular carcinoma model in immunocompetent rats. We analysed the pharmacokinetic profile of the less toxic photoform ("ring-closed" dithienylethene) of the compound in tumors, plasma, and healthy liver. Accordingly, the peptide can reach a tumor concentration sufficiently high to exert a cytotoxic effect upon photoconversion into the more active ("ring-open") photoform. Tissue morphology, histology, redox state of the liver, and hepatic biochemical parameters in blood serum were analysed upon treatment with (i) the less active photoform, (ii) the in vivo light-activated alternative photoform, and (iii) compared with a reference chemotherapeutic 5-fluorouracil. We found that application of the less toxic form followed by a delayed in vivo photoconversion into the more toxic ring-open form of LMB040 led to a higher overall survival of the animals, and signs of enhanced immune response were observed compared to the untreated animals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anticancer peptides | |
| 650 | 4 | |a Hepatocellular carcinoma | |
| 650 | 4 | |a Molecular photoswitches | |
| 650 | 4 | |a Pharmacodynamics | |
| 650 | 4 | |a Pharmacokinetics | |
| 650 | 4 | |a Photopharmacology | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 650 | 7 | |a Peptides |2 NLM | |
| 650 | 7 | |a Fluorouracil |2 NLM | |
| 650 | 7 | |a U3P01618RT |2 NLM | |
| 700 | 1 | |a Tolstanova, Ganna |e verfasserin |4 aut | |
| 700 | 1 | |a Kuznietsova, Halyna |e verfasserin |4 aut | |
| 700 | 1 | |a Dziubenko, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Yanchuk, Petro I |e verfasserin |4 aut | |
| 700 | 1 | |a Shtanova, Lydia Y |e verfasserin |4 aut | |
| 700 | 1 | |a Veselsky, Stanislav P |e verfasserin |4 aut | |
| 700 | 1 | |a Garmanchuk, Liudmyla V |e verfasserin |4 aut | |
| 700 | 1 | |a Khranovska, Nataliia |e verfasserin |4 aut | |
| 700 | 1 | |a Gorbach, Oleksandr |e verfasserin |4 aut | |
| 700 | 1 | |a Dovbynchuk, Taisa |e verfasserin |4 aut | |
| 700 | 1 | |a Borysko, Petro |e verfasserin |4 aut | |
| 700 | 1 | |a Babii, Oleg |e verfasserin |4 aut | |
| 700 | 1 | |a Schober, Tim |e verfasserin |4 aut | |
| 700 | 1 | |a Ulrich, Anne S |e verfasserin |4 aut | |
| 700 | 1 | |a Afonin, Sergii |e verfasserin |4 aut | |
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