The utility of SARS-CoV-2 nucleocapsid protein in laboratory diagnosis
© 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC..
BACKGROUND: The Coronavirus Disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has now become a global pandemic owing to its high transmissibility. The SARS-CoV-2 nucleocapsid protein tests are playing an important role in screening and diagnosing patients with COVID-19, and studies about the utility of SARS-CoV-2 nucleocapsid protein tests are increasing now.
METHODS: In this review, all the relevant original studies were assessed by searching in electronic databases including Scopus, Pubmed, Embase, and Web of Science. "SARS-CoV-2", "COVID-19", "nucleocapsid protein", and "antigen detection" were used as keywords.
RESULTS: In this review, we summarized the utility of SARS-CoV-2 nucleocapsid protein in laboratory diagnosis. Among the representative researches, this review analyzed, the sensitivity of SARS-CoV-2 nucleocapsid protein detection varies from 13% to 87.9%, while the specificity could almost reach 100% in most studies. As a matter of fact, the sensitivity is around 50% and could be higher or lower due to the influential factors.
CONCLUSION: It is well suggested that SARS-CoV-2 nucleocapsid protein is a convenient method with a short turnaround time of about half an hour, and the presence of N antigen is positively related to viral transmissibility, indicating that SARS-CoV-2 N protein immunoassays contribute to finding out those infected people rapidly and segregating them from the uninfected people.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
Journal of clinical laboratory analysis - 36(2022), 7 vom: 03. Juli, Seite e24534 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Xinwei [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Viral |
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| Anmerkungen: |
Date Completed 15.07.2022 Date Revised 16.07.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jcla.24534 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. | ||
| 520 | |a BACKGROUND: The Coronavirus Disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has now become a global pandemic owing to its high transmissibility. The SARS-CoV-2 nucleocapsid protein tests are playing an important role in screening and diagnosing patients with COVID-19, and studies about the utility of SARS-CoV-2 nucleocapsid protein tests are increasing now | ||
| 520 | |a METHODS: In this review, all the relevant original studies were assessed by searching in electronic databases including Scopus, Pubmed, Embase, and Web of Science. "SARS-CoV-2", "COVID-19", "nucleocapsid protein", and "antigen detection" were used as keywords | ||
| 520 | |a RESULTS: In this review, we summarized the utility of SARS-CoV-2 nucleocapsid protein in laboratory diagnosis. Among the representative researches, this review analyzed, the sensitivity of SARS-CoV-2 nucleocapsid protein detection varies from 13% to 87.9%, while the specificity could almost reach 100% in most studies. As a matter of fact, the sensitivity is around 50% and could be higher or lower due to the influential factors | ||
| 520 | |a CONCLUSION: It is well suggested that SARS-CoV-2 nucleocapsid protein is a convenient method with a short turnaround time of about half an hour, and the presence of N antigen is positively related to viral transmissibility, indicating that SARS-CoV-2 N protein immunoassays contribute to finding out those infected people rapidly and segregating them from the uninfected people | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
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| 650 | 4 | |a antigen detection | |
| 650 | 4 | |a laboratory diagnosis | |
| 650 | 4 | |a nucleocapsid protein | |
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| 700 | 1 | |a Guo, Xiaobing |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yirong |e verfasserin |4 aut | |
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