Immunomodulatory Effects of Sinensetin on Macrophage and Cyclophosphamide-induced Immunosuppression in Mice
In this study, we investigated the immunomodulatory effects of sinensetin (SI) on RAW 264.7 macrophages and cyclophosphamide (CY)-induced immunosuppressed mice. The results showed that SI enhanced macrophage activity and promoted the secretion of NO, IL-1β, and TNF-α in vitro. Compared with the CY-induced immunosuppressed mice, in mice treated with SI, the body weights, organ indices, and total lymphocytes increased. Furthermore, SI promoted the secretion and mRNA expression of IFN-γ, IL-2, and IL-6 and reduced the damage caused by CY to the organs of the immune system. Moreover, it increased the activities of GSH-Px, CAT, SOD, and T-AOC and decreased the level of MDA. This study suggests that SI has the potential to be used as an immunity enhancer in the functional food and healthcare industries.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:77 |
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| Enthalten in: |
Die Pharmazie - 77(2022), 5 vom: 01. Mai, Seite 147-151 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Yi-Lun [VerfasserIn] |
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| Links: |
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| Themen: |
240LNZ51AT |
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| Anmerkungen: |
Date Completed 06.06.2022 Date Revised 14.06.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1691/ph.2022.2321 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM341773352 |
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| 520 | |a In this study, we investigated the immunomodulatory effects of sinensetin (SI) on RAW 264.7 macrophages and cyclophosphamide (CY)-induced immunosuppressed mice. The results showed that SI enhanced macrophage activity and promoted the secretion of NO, IL-1β, and TNF-α in vitro. Compared with the CY-induced immunosuppressed mice, in mice treated with SI, the body weights, organ indices, and total lymphocytes increased. Furthermore, SI promoted the secretion and mRNA expression of IFN-γ, IL-2, and IL-6 and reduced the damage caused by CY to the organs of the immune system. Moreover, it increased the activities of GSH-Px, CAT, SOD, and T-AOC and decreased the level of MDA. This study suggests that SI has the potential to be used as an immunity enhancer in the functional food and healthcare industries | ||
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