Salvage surgery in recurrent sinonasal cancers : Proposal for a prognostic model based on clinicopathologic and treatment-related parameters
© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC..
BACKGROUND: Evidence on survival and major prognosticators after salvage surgery in recurrent sinonasal cancers (SNC) is limited.
METHODS: A retrospective, single-center study of recurrent SNC treated with salvage surgery between 1997 and 2019 was conducted. Univariate and multivariable analyses were performed to define a prognostic score for overall survival (OS).
RESULTS: One hundred and eighteen patients were included. Recurrent SNC originated mostly in the naso-ethmoidal box (67.8%) and were mainly epithelial (76.2%), high-grade (49.2%), and locally advanced (rpT4, 60.1%) malignancies. Negative margins were achieved in 56.6% of cases. Two- and 5-year OS were 71.7% and 56%, respectively. The prognostic model included treatment modality for primary tumor, histology, rpT class, margin status, perineural invasion, and adjuvant radiotherapy and stratified patients into three prognostic groups (5-year OS: 84.4%, 44.9%, and 0%, respectively).
CONCLUSIONS: Treatment of recurrent SNC can result in good long-term survival estimates with limited morbidity. Our score can provide excellent prognostic stratification.
| Errataetall: |
CommentIn: Head Neck. 2023 Feb;45(2):537-539. - PMID 36394120 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Head & neck - 44(2022), 8 vom: 01. Aug., Seite 1857-1870 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mattavelli, Davide [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 07.07.2022 Date Revised 16.02.2023 published: Print-Electronic CommentIn: Head Neck. 2023 Feb;45(2):537-539. - PMID 36394120 Citation Status MEDLINE |
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| doi: |
10.1002/hed.27102 |
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NLM341743933 |
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| 500 | |a CommentIn: Head Neck. 2023 Feb;45(2):537-539. - PMID 36394120 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Authors. Head & Neck published by Wiley Periodicals LLC. | ||
| 520 | |a BACKGROUND: Evidence on survival and major prognosticators after salvage surgery in recurrent sinonasal cancers (SNC) is limited | ||
| 520 | |a METHODS: A retrospective, single-center study of recurrent SNC treated with salvage surgery between 1997 and 2019 was conducted. Univariate and multivariable analyses were performed to define a prognostic score for overall survival (OS) | ||
| 520 | |a RESULTS: One hundred and eighteen patients were included. Recurrent SNC originated mostly in the naso-ethmoidal box (67.8%) and were mainly epithelial (76.2%), high-grade (49.2%), and locally advanced (rpT4, 60.1%) malignancies. Negative margins were achieved in 56.6% of cases. Two- and 5-year OS were 71.7% and 56%, respectively. The prognostic model included treatment modality for primary tumor, histology, rpT class, margin status, perineural invasion, and adjuvant radiotherapy and stratified patients into three prognostic groups (5-year OS: 84.4%, 44.9%, and 0%, respectively) | ||
| 520 | |a CONCLUSIONS: Treatment of recurrent SNC can result in good long-term survival estimates with limited morbidity. Our score can provide excellent prognostic stratification | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a prognostic score | |
| 650 | 4 | |a recurrence | |
| 650 | 4 | |a salvage surgery | |
| 650 | 4 | |a sinonasal cancer | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Tomasoni, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrari, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Compagnoni, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Schreiber, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Taboni, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Rampinelli, Vittorio |e verfasserin |4 aut | |
| 700 | 1 | |a Marazzi, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Raffetti, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Redaelli de Zinis, Luca Oscar |e verfasserin |4 aut | |
| 700 | 1 | |a Deganello, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Maroldi, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Bossi, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Piazza, Cesare |e verfasserin |4 aut | |
| 700 | 1 | |a Nicolai, Piero |e verfasserin |4 aut | |
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