Plasma p-tau181 associated with structural changes in mild cognitive impairment
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG..
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with dementia and is a serious concern for the health of individuals and government health care systems worldwide. Gray matter atrophy and white matter damage are major contributors to cognitive deficits in AD patients, as demonstrated by magnetic resonance imaging (MRI). Many of these brain changes associated with AD begin to occur about 15 years before the onset of initial clinical symptoms. Therefore, it is critical to find biomarkers reflective of these brain changes associated with AD to identify this disease and monitor its prognosis and development. The increased plasma level of hyperphosphorylated tau 181 (p-tau181) has been recently considered a novel biomarker for the diagnosis of AD, preclinical AD, and mild cognitive impairment (MCI). In the current study, we examined the association of cerebrospinal fluid (CSF) and plasma levels of p-tau181 with structural brain changes in cortical thickness, cortical volume, surface area, and subcortical volume in MCI patients. In this cross-sectional study, we included the information of 461 MCI patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. The results of voxel-wise partial correlation analyses showed a significant negative correlation between the increased levels of plasma p-tau181, CSF total tau, and CSF p-tau181 with structural changes in widespread brain regions. These results provide evidence for the use of plasma p-tau181 as a diagnostic marker for structural changes in the brain associated with the early stages of AD and neurodegeneration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Aging clinical and experimental research - 34(2022), 9 vom: 01. Sept., Seite 2139-2147 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nabizadeh, Fardin [VerfasserIn] |
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| Links: |
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| Themen: |
Atrophy |
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| Anmerkungen: |
Date Completed 13.09.2022 Date Revised 28.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s40520-022-02148-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM341703699 |
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| 520 | |a © 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG. | ||
| 520 | |a Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with dementia and is a serious concern for the health of individuals and government health care systems worldwide. Gray matter atrophy and white matter damage are major contributors to cognitive deficits in AD patients, as demonstrated by magnetic resonance imaging (MRI). Many of these brain changes associated with AD begin to occur about 15 years before the onset of initial clinical symptoms. Therefore, it is critical to find biomarkers reflective of these brain changes associated with AD to identify this disease and monitor its prognosis and development. The increased plasma level of hyperphosphorylated tau 181 (p-tau181) has been recently considered a novel biomarker for the diagnosis of AD, preclinical AD, and mild cognitive impairment (MCI). In the current study, we examined the association of cerebrospinal fluid (CSF) and plasma levels of p-tau181 with structural brain changes in cortical thickness, cortical volume, surface area, and subcortical volume in MCI patients. In this cross-sectional study, we included the information of 461 MCI patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. The results of voxel-wise partial correlation analyses showed a significant negative correlation between the increased levels of plasma p-tau181, CSF total tau, and CSF p-tau181 with structural changes in widespread brain regions. These results provide evidence for the use of plasma p-tau181 as a diagnostic marker for structural changes in the brain associated with the early stages of AD and neurodegeneration | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Atrophy | |
| 650 | 4 | |a Blood biomarker | |
| 650 | 4 | |a Mild cognitive impairment | |
| 650 | 4 | |a p-tau181 | |
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| 700 | 1 | |a Rostami, Mohammad Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Ward, Richard T |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmadi, Niloufar |e verfasserin |4 aut | |
| 700 | 1 | |a Pourhamzeh, Mahsa |e verfasserin |4 aut | |
| 700 | 0 | |a Alzheimer’s disease Neuroimaging Initiative (ADNI) |e verfasserin |4 aut | |
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