Improvement of Sleep Disorders During a Course of Radiotherapy for Breast Cancer - Final Results of the Prospective Interventional RADIO-SLEEP Trial
Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved..
BACKGROUND/AIM: Upcoming radiotherapy may cause distress and sleep disorders (SDO). This prospective interventional trial investigated SDO during a course of radiotherapy for breast cancer.
PATIENTS AND METHODS: Fifty patients were eligible. The primary endpoint was improvement of SDO after 15 fractions. Additional endpoints included SDO after 5 fractions and at the end of radiotherapy (EOT). Additional characteristics were analysed including use of smartphones/tablets, age, body mass index, performance score, comorbidity score, surgery, distress score, and emotional/ physical/practical problems.
RESULTS: After 15 fractions, 38% of patients reported improvement of SDO (p<0.0001). Improvement rates were 22% after 5 fractions (p=0.003) and 39% at EOT (p<0.0001). Moreover, a significant association was observed for lower distress score after 5 fractions.
CONCLUSION: Improvement of SDO occurred more often than expected, most likely due to habituation to radiotherapy. Since SDO did not improve in the majority of patients, timely psychological support should be offered to all patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
|---|---|
| Enthalten in: |
Anticancer research - 42(2022), 6 vom: 01. Juni, Seite 3085-3089 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rades, Dirk [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Adjuvant radiotherapy |
|---|
| Anmerkungen: |
Date Completed 02.06.2022 Date Revised 06.06.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.21873/anticanres.15796 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM341634433 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM341634433 | ||
| 003 | DE-627 | ||
| 005 | 20231226012231.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21873/anticanres.15796 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1138.xml |
| 035 | |a (DE-627)NLM341634433 | ||
| 035 | |a (NLM)35641281 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Rades, Dirk |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Improvement of Sleep Disorders During a Course of Radiotherapy for Breast Cancer - Final Results of the Prospective Interventional RADIO-SLEEP Trial |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.06.2022 | ||
| 500 | |a Date Revised 06.06.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. | ||
| 520 | |a BACKGROUND/AIM: Upcoming radiotherapy may cause distress and sleep disorders (SDO). This prospective interventional trial investigated SDO during a course of radiotherapy for breast cancer | ||
| 520 | |a PATIENTS AND METHODS: Fifty patients were eligible. The primary endpoint was improvement of SDO after 15 fractions. Additional endpoints included SDO after 5 fractions and at the end of radiotherapy (EOT). Additional characteristics were analysed including use of smartphones/tablets, age, body mass index, performance score, comorbidity score, surgery, distress score, and emotional/ physical/practical problems | ||
| 520 | |a RESULTS: After 15 fractions, 38% of patients reported improvement of SDO (p<0.0001). Improvement rates were 22% after 5 fractions (p=0.003) and 39% at EOT (p<0.0001). Moreover, a significant association was observed for lower distress score after 5 fractions | ||
| 520 | |a CONCLUSION: Improvement of SDO occurred more often than expected, most likely due to habituation to radiotherapy. Since SDO did not improve in the majority of patients, timely psychological support should be offered to all patients | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Breast cancer | |
| 650 | 4 | |a adjuvant radiotherapy | |
| 650 | 4 | |a patient reported outcomes | |
| 650 | 4 | |a prospective trial | |
| 650 | 4 | |a sleep disorders | |
| 700 | 1 | |a Narvaez, Carlos A |e verfasserin |4 aut | |
| 700 | 1 | |a Dziggel, Liesa |e verfasserin |4 aut | |
| 700 | 1 | |a Splettstösser, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Janssen, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Olbrich, Denise |e verfasserin |4 aut | |
| 700 | 1 | |a Schild, Steven E |e verfasserin |4 aut | |
| 700 | 1 | |a Tvilsted, Søren |e verfasserin |4 aut | |
| 700 | 1 | |a Kjaer, Troels W |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anticancer research |d 1987 |g 42(2022), 6 vom: 01. Juni, Seite 3085-3089 |w (DE-627)NLM012601454 |x 1791-7530 |7 nnns |
| 773 | 1 | 8 | |g volume:42 |g year:2022 |g number:6 |g day:01 |g month:06 |g pages:3085-3089 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.21873/anticanres.15796 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 42 |j 2022 |e 6 |b 01 |c 06 |h 3085-3089 | ||