Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets
© The Author(s) 2022. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
This study investigated whether bamboo leaf extract (BLE) could improve the growth performance, antioxidant capacity, and inhibit hepatic apoptosis in suckling piglets. Sixty-four suckling piglets were orally gavaged with vehicle (CON group) or 100, 200, or 300 mg BLE/kg body weight (BL, BM, and BH groups) at 3 d of age for 21 d (n = 8). The results showed that BLE treatment had no effects on the growth performance (P > 0.05). Compared with the CON group, the BM and BH groups decreased (P < 0.05) the jejunal and hepatic malondialdehyde (MDA) contents. Supplementation with BLE increased antioxidant enzymes activities and the expressions of nuclear factor erythroid 2-related factor 2 (Nrf2) and several targeted genes in the jejunum and liver of suckling piglets. The hepatic apoptosis rate was lower (P < 0.05) in BLE treatment than in the CON group. Compared with the CON group, the BLE groups showed increased (P < 0.05) mRNA levels of B-cell-lymphoma protein 2 (BCL-2), whereas decreased (P < 0.05) BCL-2-associated X (BAX) and cysteine aspartate specific protease-3 (caspase-3) mRNA levels. The results of protein expressions of BCL-2 and caspase-3 were consistent with those of mRNA levels. Altogether, our results indicated that BLE intervention can improve the antioxidant capacity and inhibit hepatic apoptosis in suckling piglets.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:100 |
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| Enthalten in: |
Journal of animal science - 100(2022), 7 vom: 01. Juli |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yu, Ge [VerfasserIn] |
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| Links: |
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| Themen: |
Antioxidant capacity |
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| Anmerkungen: |
Date Completed 08.07.2022 Date Revised 01.06.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/jas/skac201 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM341632953 |
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| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a This study investigated whether bamboo leaf extract (BLE) could improve the growth performance, antioxidant capacity, and inhibit hepatic apoptosis in suckling piglets. Sixty-four suckling piglets were orally gavaged with vehicle (CON group) or 100, 200, or 300 mg BLE/kg body weight (BL, BM, and BH groups) at 3 d of age for 21 d (n = 8). The results showed that BLE treatment had no effects on the growth performance (P > 0.05). Compared with the CON group, the BM and BH groups decreased (P < 0.05) the jejunal and hepatic malondialdehyde (MDA) contents. Supplementation with BLE increased antioxidant enzymes activities and the expressions of nuclear factor erythroid 2-related factor 2 (Nrf2) and several targeted genes in the jejunum and liver of suckling piglets. The hepatic apoptosis rate was lower (P < 0.05) in BLE treatment than in the CON group. Compared with the CON group, the BLE groups showed increased (P < 0.05) mRNA levels of B-cell-lymphoma protein 2 (BCL-2), whereas decreased (P < 0.05) BCL-2-associated X (BAX) and cysteine aspartate specific protease-3 (caspase-3) mRNA levels. The results of protein expressions of BCL-2 and caspase-3 were consistent with those of mRNA levels. Altogether, our results indicated that BLE intervention can improve the antioxidant capacity and inhibit hepatic apoptosis in suckling piglets | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a antioxidant capacity | |
| 650 | 4 | |a apoptosis | |
| 650 | 4 | |a bamboo leaf extract | |
| 650 | 4 | |a suckling piglets | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
| 650 | 7 | |a Proto-Oncogene Proteins c-bcl-2 |2 NLM | |
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| 700 | 1 | |a Ji, Shuli |e verfasserin |4 aut | |
| 700 | 1 | |a Yun, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Kang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Peilu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Tian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Lili |e verfasserin |4 aut | |
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