Epidemiology and Molecular Analyses of Influenza B Viruses in Senegal from 2010 to 2019
Influenza virus types A and B are responsible for acute viral infections that affect annually 1 billion people, with 290,000 to 650,000 deaths worldwide. In this study, we investigated the circulation of influenza B viruses over a 10-year period (2010-2019). Specimens from patients suspected of influenza infection were collected. Influenza detection was performed following RNA extraction and real-time RT-PCR. Genes coding for hemagglutinin (HA) and neuraminidase (NA) of influenza B viruses were partially sequenced, and phylogenetic analyses were carried out subsequently. During the study period, we received and tested a total of 15,156 specimens. Influenza B virus was detected in 1322 (8.7%) specimens. The mean age of influenza B positive patients was 10.9 years. When compared to reference viruses, HA genes from Senegalese circulating viruses showed deletions in the HA1 region. Phylogenetic analysis highlighted the co-circulation of B/Victoria and B/Yamagata lineage viruses with reassortant viruses. We also noted a clear seasonal pattern of circulation of influenza B viruses in Senegal.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Viruses - 14(2022), 5 vom: 16. Mai |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Touré, Cheikh Talibouya [VerfasserIn] |
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| Links: |
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| Themen: |
Africa |
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| Anmerkungen: |
Date Completed 31.05.2022 Date Revised 16.07.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/v14051063 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Influenza virus types A and B are responsible for acute viral infections that affect annually 1 billion people, with 290,000 to 650,000 deaths worldwide. In this study, we investigated the circulation of influenza B viruses over a 10-year period (2010-2019). Specimens from patients suspected of influenza infection were collected. Influenza detection was performed following RNA extraction and real-time RT-PCR. Genes coding for hemagglutinin (HA) and neuraminidase (NA) of influenza B viruses were partially sequenced, and phylogenetic analyses were carried out subsequently. During the study period, we received and tested a total of 15,156 specimens. Influenza B virus was detected in 1322 (8.7%) specimens. The mean age of influenza B positive patients was 10.9 years. When compared to reference viruses, HA genes from Senegalese circulating viruses showed deletions in the HA1 region. Phylogenetic analysis highlighted the co-circulation of B/Victoria and B/Yamagata lineage viruses with reassortant viruses. We also noted a clear seasonal pattern of circulation of influenza B viruses in Senegal | ||
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| 700 | 1 | |a Goudiaby, Deborah |e verfasserin |4 aut | |
| 700 | 1 | |a Kiori, Davy |e verfasserin |4 aut | |
| 700 | 1 | |a Sy, Sara |e verfasserin |4 aut | |
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| 700 | 1 | |a Mbaye, Fatimata |e verfasserin |4 aut | |
| 700 | 1 | |a Niang, Mbayang Ndiaye |e verfasserin |4 aut | |
| 700 | 1 | |a Heraud, Jean Michel |e verfasserin |4 aut | |
| 700 | 1 | |a Dia, Ndongo |e verfasserin |4 aut | |
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