Forming a Double-Helix Phase of Single Polymer Chains by the Cooperation between Local Structure and Nonlocal Attraction
Double-helix structures, such as DNA, are formed in nature to realize many unique functions. Inspired by this, researchers are pursuing strategies to design such structures from polymers. A key question is whether the double helix can be formed from the self-folding of a single polymer chain without specific interactions. Here, using Langevin dynamics simulation and theoretical analysis, we find that a stable double-helix phase can be achieved by the self-folding of single semiflexible polymers as a result of the cooperation between local structure and nonlocal attraction. The critical temperature of double-helix formation approximately follows T^{cri}∼ln(k_{θ}) and T^{cri}∼ln(k_{τ}), where k_{θ} and k_{τ} are the polymer bending and torsion stiffness, respectively. Furthermore, the double helix can exhibit major and minor grooves due to symmetric break for better packing. Our results provide a novel guide to the experimental design of the double helix.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:128 |
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| Enthalten in: |
Physical review letters - 128(2022), 19 vom: 13. Mai, Seite 197801 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Du, Jiang [VerfasserIn] |
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Date Completed 31.05.2022 Date Revised 31.05.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1103/PhysRevLett.128.197801 |
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| PPN (Katalog-ID): |
NLM34144362X |
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| 520 | |a Double-helix structures, such as DNA, are formed in nature to realize many unique functions. Inspired by this, researchers are pursuing strategies to design such structures from polymers. A key question is whether the double helix can be formed from the self-folding of a single polymer chain without specific interactions. Here, using Langevin dynamics simulation and theoretical analysis, we find that a stable double-helix phase can be achieved by the self-folding of single semiflexible polymers as a result of the cooperation between local structure and nonlocal attraction. The critical temperature of double-helix formation approximately follows T^{cri}∼ln(k_{θ}) and T^{cri}∼ln(k_{τ}), where k_{θ} and k_{τ} are the polymer bending and torsion stiffness, respectively. Furthermore, the double helix can exhibit major and minor grooves due to symmetric break for better packing. Our results provide a novel guide to the experimental design of the double helix | ||
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| 700 | 1 | |a Yin, Hongmei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Haoqi |e verfasserin |4 aut | |
| 700 | 1 | |a Wan, Tiantian |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Binzhou |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Hongtao |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Yanfang |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Tao |e verfasserin |4 aut | |
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