Multicentre match-paired analysis of advanced biliary cancer long-term survivors : The BILONG study
Copyright © 2022 Elsevier Masson SAS. All rights reserved..
BACKGROUND: Advanced biliary cancers (ABC) are aggressive malignancies with a median overall survival (mOS) <12 months when treated with first-line chemotherapy. Nevertheless, a subset of patients experiencing longer survival has been described in the updated analysis of ABC-02 trial. We aimed to provide a real-world description of ABC long-term survivors (LS), identifying which factors impact on survival.
METHODS: Patients diagnosed with ABC at three Institutions between 2002 and 2019, and who survived ≥18 months, were retrospectively identified. We compared them with a control cohort (C) with a mOS <18 months, matched on age, gender, ECOG PS, disease status, primary tumor site, prior surgery, and treatment modality. Their clinical features, treatments, and outcome were analyzed.
RESULTS: A total of 78 patients was included, 39 in each group. Both LS and C cohorts had superimposable baseline characteristics, without significant differences. mOS was 29 (95%CI 24.6-33.5) and 9 months (95%CI 6.6-12.9) in the two groups, respectively. After performing a logistic regression analysis, three factors were significantly associated with long-term outcome: low neutrophil-to-lymphocyte ratio (NLR < 3) (Odds Ratio [OR] 0.38), achievement of objective response to treatment (OR 0.16), and the number of lines received (OR 0.29).
CONCLUSIONS: We described a considerable subset of ABC experiencing long-term survival with conventional chemotherapy in a real-world scenario. Beyond clinical factors, we identified low NLR as a prognostic determinant that may allow for a more accurate selection of long survivors. While waiting for a deeper molecular characterization of this subgroup, we propose NLR as a stratification factor for daily practice and clinical trials.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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Enthalten in: |
Clinics and research in hepatology and gastroenterology - 46(2022), 8 vom: 24. Okt., Seite 101955 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Caputo, Francesco [VerfasserIn] |
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Links: |
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Themen: |
Biliary cancer |
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Anmerkungen: |
Date Completed 05.10.2022 Date Revised 23.12.2022 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.clinre.2022.101955 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM341322539 |
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520 | |a Copyright © 2022 Elsevier Masson SAS. All rights reserved. | ||
520 | |a BACKGROUND: Advanced biliary cancers (ABC) are aggressive malignancies with a median overall survival (mOS) <12 months when treated with first-line chemotherapy. Nevertheless, a subset of patients experiencing longer survival has been described in the updated analysis of ABC-02 trial. We aimed to provide a real-world description of ABC long-term survivors (LS), identifying which factors impact on survival | ||
520 | |a METHODS: Patients diagnosed with ABC at three Institutions between 2002 and 2019, and who survived ≥18 months, were retrospectively identified. We compared them with a control cohort (C) with a mOS <18 months, matched on age, gender, ECOG PS, disease status, primary tumor site, prior surgery, and treatment modality. Their clinical features, treatments, and outcome were analyzed | ||
520 | |a RESULTS: A total of 78 patients was included, 39 in each group. Both LS and C cohorts had superimposable baseline characteristics, without significant differences. mOS was 29 (95%CI 24.6-33.5) and 9 months (95%CI 6.6-12.9) in the two groups, respectively. After performing a logistic regression analysis, three factors were significantly associated with long-term outcome: low neutrophil-to-lymphocyte ratio (NLR < 3) (Odds Ratio [OR] 0.38), achievement of objective response to treatment (OR 0.16), and the number of lines received (OR 0.29) | ||
520 | |a CONCLUSIONS: We described a considerable subset of ABC experiencing long-term survival with conventional chemotherapy in a real-world scenario. Beyond clinical factors, we identified low NLR as a prognostic determinant that may allow for a more accurate selection of long survivors. While waiting for a deeper molecular characterization of this subgroup, we propose NLR as a stratification factor for daily practice and clinical trials | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Multicenter Study | |
650 | 4 | |a Biliary cancer | |
650 | 4 | |a Chemotherapy | |
650 | 4 | |a Cholangiocarcinoma | |
650 | 4 | |a Gallbladder cancer | |
650 | 4 | |a Long-term survivors | |
650 | 4 | |a Prognosis | |
650 | 4 | |a Survival | |
700 | 1 | |a Gelsomino, Fabio |e verfasserin |4 aut | |
700 | 1 | |a Spallanzani, Andrea |e verfasserin |4 aut | |
700 | 1 | |a Pettorelli, Elisa |e verfasserin |4 aut | |
700 | 1 | |a Benatti, Stefania |e verfasserin |4 aut | |
700 | 1 | |a Ghidini, Michele |e verfasserin |4 aut | |
700 | 1 | |a Grizzi, Giulia |e verfasserin |4 aut | |
700 | 1 | |a Ratti, Margherita |e verfasserin |4 aut | |
700 | 1 | |a Merz, Valeria |e verfasserin |4 aut | |
700 | 1 | |a Messina, Carlo |e verfasserin |4 aut | |
700 | 1 | |a Tonelli, Roberto |e verfasserin |4 aut | |
700 | 1 | |a Luppi, Gabriele |e verfasserin |4 aut | |
700 | 1 | |a Melisi, Davide |e verfasserin |4 aut | |
700 | 1 | |a Dominici, Massimo |e verfasserin |4 aut | |
700 | 1 | |a Salati, Massimiliano |e verfasserin |4 aut | |
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