Oligo-layer graphene stabilized fully exposed Fe-sites for ultra-sensitivity electrochemical detection of dopamine
Copyright © 2022 Elsevier B.V. All rights reserved..
Neurotransmitter dopamine (DA) has been implicated in a variety of physiological and pathological processes, realizing its low detection limit and high sensitivity analysis is of great significance for early disease diagnosis. Herein, we propose a simple pyrolysis approach for dispersing Fe-sites onto the N-doped graphene support (denoted as Fe/N-GR) to construct an electrochemical biosensor for DA detection. The fully exposed Fe-sites guaranteed the well-defined active center for electrochemical oxidation of DA. The Fe/N-GR electrochemical biosensor achieves an ultra-low detection limit for DA of 27 pM with a linear range of 50 pM-15 nM. Specifically, the Fe/N-GR electrochemical biosensor exhibits favorable sensitivity and enzyme-level molecular identification ability in the selective detection of DA versus other typical redox-active interferents. What's more, the detection of dopamine in real human serum samples verifies the applicability of the developed sensor. Our results demonstrate a promising means of using fully exposed metal-site subnanometric catalysts for electrochemical sensing applications.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:211 |
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| Enthalten in: |
Biosensors & bioelectronics - 211(2022) vom: 01. Sept., Seite 114367 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sun, Zejun [VerfasserIn] |
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| Links: |
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| Themen: |
7782-42-5 |
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| Anmerkungen: |
Date Completed 14.06.2022 Date Revised 14.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bios.2022.114367 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM341280461 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier B.V. All rights reserved. | ||
| 520 | |a Neurotransmitter dopamine (DA) has been implicated in a variety of physiological and pathological processes, realizing its low detection limit and high sensitivity analysis is of great significance for early disease diagnosis. Herein, we propose a simple pyrolysis approach for dispersing Fe-sites onto the N-doped graphene support (denoted as Fe/N-GR) to construct an electrochemical biosensor for DA detection. The fully exposed Fe-sites guaranteed the well-defined active center for electrochemical oxidation of DA. The Fe/N-GR electrochemical biosensor achieves an ultra-low detection limit for DA of 27 pM with a linear range of 50 pM-15 nM. Specifically, the Fe/N-GR electrochemical biosensor exhibits favorable sensitivity and enzyme-level molecular identification ability in the selective detection of DA versus other typical redox-active interferents. What's more, the detection of dopamine in real human serum samples verifies the applicability of the developed sensor. Our results demonstrate a promising means of using fully exposed metal-site subnanometric catalysts for electrochemical sensing applications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Dopamine | |
| 650 | 4 | |a Electrochemical biosensor | |
| 650 | 4 | |a Fully exposed Fe-Sites | |
| 650 | 4 | |a Oligo-layer graphene | |
| 650 | 4 | |a Subnanometric catalysts | |
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| 650 | 7 | |a 7782-42-5 |2 NLM | |
| 650 | 7 | |a Dopamine |2 NLM | |
| 650 | 7 | |a VTD58H1Z2X |2 NLM | |
| 700 | 1 | |a Sun, Shuang |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Xue |e verfasserin |4 aut | |
| 700 | 1 | |a Ai, Yongjian |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Wenjuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Liping |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Hong-Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Qionglin |e verfasserin |4 aut | |
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