Influence of maternal obesity on the multi-omics profiles of the maternal body, gestational tissue, and offspring
Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved..
Epidemiological studies show that obesity during pregnancy affects more than half of the pregnancies in the developed countries and is associated with obstetric problems and poor outcomes. Obesity tends to increase the incidence of complications. Furthermore, the resulting offspring are also adversely affected. However, the molecular mechanisms of obesity leading to poor pregnancy outcomes remain unclear. Omics methods are used for genetic diagnosis and marker discovery. The aim of this review was to summarize the maternal and fetal pathophysiological alterations induced by gestational obesity,identified using multi-omics detection techniques, and to generalize the biological functions and potential mechanisms of the differentially expressed molecules.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:151 |
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| Enthalten in: |
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 151(2022) vom: 08. Juli, Seite 113103 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Duan [VerfasserIn] |
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| Links: |
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| Themen: |
Epigenetics |
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| Anmerkungen: |
Date Completed 08.06.2022 Date Revised 08.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.biopha.2022.113103 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved. | ||
| 520 | |a Epidemiological studies show that obesity during pregnancy affects more than half of the pregnancies in the developed countries and is associated with obstetric problems and poor outcomes. Obesity tends to increase the incidence of complications. Furthermore, the resulting offspring are also adversely affected. However, the molecular mechanisms of obesity leading to poor pregnancy outcomes remain unclear. Omics methods are used for genetic diagnosis and marker discovery. The aim of this review was to summarize the maternal and fetal pathophysiological alterations induced by gestational obesity,identified using multi-omics detection techniques, and to generalize the biological functions and potential mechanisms of the differentially expressed molecules | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Epigenetics | |
| 650 | 4 | |a Maternal obesity | |
| 650 | 4 | |a Metabolomics | |
| 650 | 4 | |a Offspring | |
| 650 | 4 | |a Proteomics | |
| 650 | 4 | |a Transcriptomics | |
| 700 | 1 | |a Liu, Yusi |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Shanshan |e verfasserin |4 aut | |
| 700 | 1 | |a He, Yiwen |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Xiaowei |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Wenting |e verfasserin |4 aut | |
| 700 | 1 | |a Gu, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, Zhengwei |e verfasserin |4 aut | |
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