UT-Heart : A Finite Element Model Designed for the Multiscale and Multiphysics Integration of our Knowledge on the Human Heart
© 2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply..
To fully understand the health and pathology of the heart, it is necessary to integrate knowledge accumulated at molecular, cellular, tissue, and organ levels. However, it is difficult to comprehend the complex interactions occurring among the building blocks of biological systems across these scales. Recent advances in computational science supported by innovative high-performance computer hardware make it possible to develop a multiscale multiphysics model simulating the heart, in which the behavior of each cell model is controlled by molecular mechanisms and the cell models themselves are arranged to reproduce elaborate tissue structures. Such a simulator could be used as a tool not only in basic science but also in clinical settings. Here, we describe a multiscale multiphysics heart simulator, UT-Heart, which uses unique technologies to realize the abovementioned features. As examples of its applications, models for cardiac resynchronization therapy and surgery for congenital heart disease will be also shown.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2399 |
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| Enthalten in: |
Methods in molecular biology (Clifton, N.J.) - 2399(2022) vom: 23., Seite 221-245 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sugiura, Seiryo [VerfasserIn] |
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| Links: |
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| Themen: |
Finite-element method |
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| Anmerkungen: |
Date Completed 25.05.2022 Date Revised 31.05.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/978-1-0716-1831-8_10 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a To fully understand the health and pathology of the heart, it is necessary to integrate knowledge accumulated at molecular, cellular, tissue, and organ levels. However, it is difficult to comprehend the complex interactions occurring among the building blocks of biological systems across these scales. Recent advances in computational science supported by innovative high-performance computer hardware make it possible to develop a multiscale multiphysics model simulating the heart, in which the behavior of each cell model is controlled by molecular mechanisms and the cell models themselves are arranged to reproduce elaborate tissue structures. Such a simulator could be used as a tool not only in basic science but also in clinical settings. Here, we describe a multiscale multiphysics heart simulator, UT-Heart, which uses unique technologies to realize the abovementioned features. As examples of its applications, models for cardiac resynchronization therapy and surgery for congenital heart disease will be also shown | ||
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| 700 | 1 | |a Hisada, Toshiaki |e verfasserin |4 aut | |
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