Abnormal Visual Evoked Responses to Emotional Cues Correspond to Diagnosis and Disease Severity in Fibromyalgia
Copyright © 2022 Goldway, Petro, Ablin, Keil, Ben Simon, Zamir, Weizman, Greental, Hendler and Sharon..
Background: Chronic pain disorders are often associated with cognitive-emotional dysregulation. However, the relations between such dysregulation, underlying brain processes, and clinical symptom constellations, remain unclear. Here, we aimed to characterize the abnormalities in cognitive-emotional processing involved in fibromyalgia syndrome (FMS) and their relation to disease severity.
Methods: Fifty-eight participants, 39 FMS patients (35F), and 19 healthy control subjects (16F) performed an EEG-based paradigm assessing attention allocation by extracting steady-state visually evoked potentials (ssVEP) in response to affective distractors presented during a cognitive task. Patients were also evaluated for pain severity, sleep quality, depression, and anxiety.
Results: EEG ssVEP measurement indicated that, compared to healthy controls, FMS patients displayed impaired affective discrimination, and sustained attention to negative distractors. Moreover, patients displayed decreased task-related fronto-occipital EEG connectivity. Lack of adaptive attentional discrimination, measured via EEG, was predictive of pain severity, while impairments in fronto-occipital connectivity were predictive of impaired sleep.
Conclusions: FMS patients display maladaptive affective attention modulation, which predicts disease symptoms. These findings support the centrality of cognitive-emotional dysregulation in the pathophysiology of chronic pain.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Frontiers in behavioral neuroscience - 16(2022) vom: 17., Seite 852133 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Goldway, Noam [VerfasserIn] |
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| Links: |
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| Themen: |
Attention bias dynamics |
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| Anmerkungen: |
Date Revised 16.09.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fnbeh.2022.852133 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM341235563 |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2022 Goldway, Petro, Ablin, Keil, Ben Simon, Zamir, Weizman, Greental, Hendler and Sharon. | ||
| 520 | |a Background: Chronic pain disorders are often associated with cognitive-emotional dysregulation. However, the relations between such dysregulation, underlying brain processes, and clinical symptom constellations, remain unclear. Here, we aimed to characterize the abnormalities in cognitive-emotional processing involved in fibromyalgia syndrome (FMS) and their relation to disease severity | ||
| 520 | |a Methods: Fifty-eight participants, 39 FMS patients (35F), and 19 healthy control subjects (16F) performed an EEG-based paradigm assessing attention allocation by extracting steady-state visually evoked potentials (ssVEP) in response to affective distractors presented during a cognitive task. Patients were also evaluated for pain severity, sleep quality, depression, and anxiety | ||
| 520 | |a Results: EEG ssVEP measurement indicated that, compared to healthy controls, FMS patients displayed impaired affective discrimination, and sustained attention to negative distractors. Moreover, patients displayed decreased task-related fronto-occipital EEG connectivity. Lack of adaptive attentional discrimination, measured via EEG, was predictive of pain severity, while impairments in fronto-occipital connectivity were predictive of impaired sleep | ||
| 520 | |a Conclusions: FMS patients display maladaptive affective attention modulation, which predicts disease symptoms. These findings support the centrality of cognitive-emotional dysregulation in the pathophysiology of chronic pain | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a EEG | |
| 650 | 4 | |a attention bias dynamics | |
| 650 | 4 | |a chronic pain & fibromyalgia | |
| 650 | 4 | |a emotion regulation | |
| 650 | 4 | |a ssVEP (steady-state visual evoked potential) | |
| 700 | 1 | |a Petro, Nathan M |e verfasserin |4 aut | |
| 700 | 1 | |a Ablin, Jacob |e verfasserin |4 aut | |
| 700 | 1 | |a Keil, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Ben Simon, Eti |e verfasserin |4 aut | |
| 700 | 1 | |a Zamir, Yoav |e verfasserin |4 aut | |
| 700 | 1 | |a Weizman, Libat |e verfasserin |4 aut | |
| 700 | 1 | |a Greental, Ayam |e verfasserin |4 aut | |
| 700 | 1 | |a Hendler, Talma |e verfasserin |4 aut | |
| 700 | 1 | |a Sharon, Haggai |e verfasserin |4 aut | |
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