Renal denervation in patients who do not respond to cardiac resynchronization therapy
Cardiac resynchronization therapy (CRT) reduces the morbidity and mortality in advanced heart failure (HF) in about two-thirds of the patients. Approximately one-third of the patients do not respond to CRT. The overactivity of sympathetic nervous system is associated with advanced HF and deteriorates the hemodynamic state. We tested the hypothesis that controlling sympathetic overactivity by renal denervation (RDN) could be beneficial in nonresponders for CRT. In our HeartF-RDN study (ClinalTrials.gov. NCT02638324), RDN could not reverse the progression of HF in subjects with New York Heart Association Classification (NYHA) III-IV stage symptoms.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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| Enthalten in: |
Scandinavian cardiovascular journal : SCJ - 56(2022), 1 vom: 09. Dez., Seite 103-106 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pietilä-Effati, Päivi [VerfasserIn] |
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| Links: |
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| Themen: |
6-minute walking test |
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| Anmerkungen: |
Date Completed 20.05.2022 Date Revised 09.06.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/14017431.2022.2060526 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM341099252 |
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| 520 | |a Cardiac resynchronization therapy (CRT) reduces the morbidity and mortality in advanced heart failure (HF) in about two-thirds of the patients. Approximately one-third of the patients do not respond to CRT. The overactivity of sympathetic nervous system is associated with advanced HF and deteriorates the hemodynamic state. We tested the hypothesis that controlling sympathetic overactivity by renal denervation (RDN) could be beneficial in nonresponders for CRT. In our HeartF-RDN study (ClinalTrials.gov. NCT02638324), RDN could not reverse the progression of HF in subjects with New York Heart Association Classification (NYHA) III-IV stage symptoms | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 6-minute walking test | |
| 650 | 4 | |a CRT nonresponder | |
| 650 | 4 | |a Cardiac resynchronization therapy | |
| 650 | 4 | |a heart failure | |
| 650 | 4 | |a renal sympathetic denervation | |
| 700 | 1 | |a Höglund, Mathias |e verfasserin |4 aut | |
| 700 | 1 | |a Käräjämäki, Aki |e verfasserin |4 aut | |
| 700 | 1 | |a Höglund, Filip |e verfasserin |4 aut | |
| 700 | 1 | |a Nabb, Anne-Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Matila, Eija |e verfasserin |4 aut | |
| 700 | 1 | |a Koistinen, M Juhani |e verfasserin |4 aut | |
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