Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection
© Royal College of Physicians 2022. All rights reserved..
OBJECTIVE: To determine the maximal response of the temperature and inflammatory response to SARS-CoV-2 infection and how these are modified by age.
METHODS: Participants were patients admitted to hospital with SARS-CoV-2 infection. For each participant, the maximal temperature and serum C-reactive protein (CRP) were identified and stratified by age. In a secondary analysis, these were compared in patients treated before and after dexamethasone.
RESULTS: Mean maximal temperature varied by age (p<0.001; ANOVA) with the highest mean maximal temperature of 37.3°C observed in patients aged 30-49 years and decreasing maximal mean temperatures in the older age groups, with the lowest measure of 36.8°C observed in individuals aged 90-99 years. The mean maximal serum CRP also varied across age groups (p<0.001; ANOVA) and increased with age across all age categories from 34.5 mg/dL (95% confidence interval (CI) 22.0-47.0) for individuals aged 20-29 years to 77.6 mg/dL (95% CI 72.0-83.2) in those aged 80-89 years. After dexamethasone became standard treatment for COVID-19 pneumonia, mean maximal CRP decreased by 17 mg/dL (95% CI -22 to -11).
CONCLUSION: Age modifies both maximal temperature and systemic inflammatory response in patients with SARS-CoV-2 infection.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|---|
| Enthalten in: |
Clinical medicine (London, England) - 22(2022), 3 vom: 24. Mai, Seite 192-196 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Crooks, Colin J [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
7S5I7G3JQL |
|---|
| Anmerkungen: |
Date Completed 20.05.2022 Date Revised 26.04.2024 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.7861/clinmed.2021-0603 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM341075892 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM341075892 | ||
| 003 | DE-627 | ||
| 005 | 20240426233029.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.7861/clinmed.2021-0603 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1388.xml |
| 035 | |a (DE-627)NLM341075892 | ||
| 035 | |a (NLM)35584822 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Crooks, Colin J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 20.05.2022 | ||
| 500 | |a Date Revised 26.04.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Royal College of Physicians 2022. All rights reserved. | ||
| 520 | |a OBJECTIVE: To determine the maximal response of the temperature and inflammatory response to SARS-CoV-2 infection and how these are modified by age | ||
| 520 | |a METHODS: Participants were patients admitted to hospital with SARS-CoV-2 infection. For each participant, the maximal temperature and serum C-reactive protein (CRP) were identified and stratified by age. In a secondary analysis, these were compared in patients treated before and after dexamethasone | ||
| 520 | |a RESULTS: Mean maximal temperature varied by age (p<0.001; ANOVA) with the highest mean maximal temperature of 37.3°C observed in patients aged 30-49 years and decreasing maximal mean temperatures in the older age groups, with the lowest measure of 36.8°C observed in individuals aged 90-99 years. The mean maximal serum CRP also varied across age groups (p<0.001; ANOVA) and increased with age across all age categories from 34.5 mg/dL (95% confidence interval (CI) 22.0-47.0) for individuals aged 20-29 years to 77.6 mg/dL (95% CI 72.0-83.2) in those aged 80-89 years. After dexamethasone became standard treatment for COVID-19 pneumonia, mean maximal CRP decreased by 17 mg/dL (95% CI -22 to -11) | ||
| 520 | |a CONCLUSION: Age modifies both maximal temperature and systemic inflammatory response in patients with SARS-CoV-2 infection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a age | |
| 650 | 4 | |a infection | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a temperature | |
| 650 | 7 | |a Dexamethasone |2 NLM | |
| 650 | 7 | |a 7S5I7G3JQL |2 NLM | |
| 650 | 7 | |a C-Reactive Protein |2 NLM | |
| 650 | 7 | |a 9007-41-4 |2 NLM | |
| 700 | 1 | |a West, Joe |e verfasserin |4 aut | |
| 700 | 1 | |a Morling, Joanne R |e verfasserin |4 aut | |
| 700 | 1 | |a Simmonds, Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Juurlink, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Briggs, Steve |e verfasserin |4 aut | |
| 700 | 1 | |a Cruickshank, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Hammond-Pears, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a Shaw, Dominick |e verfasserin |4 aut | |
| 700 | 1 | |a Card, Timothy R |e verfasserin |4 aut | |
| 700 | 1 | |a Fogarty, Andrew |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical medicine (London, England) |d 2001 |g 22(2022), 3 vom: 24. Mai, Seite 192-196 |w (DE-627)NLM112411673 |x 1473-4893 |7 nnns |
| 773 | 1 | 8 | |g volume:22 |g year:2022 |g number:3 |g day:24 |g month:05 |g pages:192-196 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.7861/clinmed.2021-0603 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 22 |j 2022 |e 3 |b 24 |c 05 |h 192-196 | ||