IgG4-Related Pancreato-Biliary Disease in the Disguise of Malignancy
The Immunoglobulin G4-related disease (IgG4-RD) is a multisystem inflammatory condition. Pancreaticobiliary manifestations often present as mass lesions that mimic malignancies. The diagnosis is confirmed by histopathological examination, that shows lymphoplasmacytic infiltration, storiform fibrosis, obliterative phlebitis, and positive immunohistochemistry for IgG4. We encountered 3 such patients in a tertiary care hospital in India. Two patients presented with obstructive jaundice and the third with pain abdomen. They had resectable lesions involving the pancreatic head, the right hepatic duct, and gallbladder fundus, respectively, on imaging. Tumor markers were not significantly elevated in any of them. All 3 patients underwent radical surgeries, suspecting malignancy. Surgical specimens showed typical features of IgG4-RD on histomorphology. Serum IgG4 level was elevated in first 2 patients but was normal in sclerosing cholecystitis patient. To conclude, IgG4-RD is a malignant mimicker; hence, on clinical suspicion, liberal attempts for tissue diagnosis may avoid radical surgeries.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
---|---|
Enthalten in: |
The American surgeon - 89(2023), 6 vom: 16. Juni, Seite 2985-2988 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Mathew, Anvin [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 28.07.2023 Date Revised 28.07.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1177/00031348221102610 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM34099407X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM34099407X | ||
003 | DE-627 | ||
005 | 20231226010737.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1177/00031348221102610 |2 doi | |
028 | 5 | 2 | |a pubmed24n1136.xml |
035 | |a (DE-627)NLM34099407X | ||
035 | |a (NLM)35576564 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Mathew, Anvin |e verfasserin |4 aut | |
245 | 1 | 0 | |a IgG4-Related Pancreato-Biliary Disease in the Disguise of Malignancy |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 28.07.2023 | ||
500 | |a Date Revised 28.07.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a The Immunoglobulin G4-related disease (IgG4-RD) is a multisystem inflammatory condition. Pancreaticobiliary manifestations often present as mass lesions that mimic malignancies. The diagnosis is confirmed by histopathological examination, that shows lymphoplasmacytic infiltration, storiform fibrosis, obliterative phlebitis, and positive immunohistochemistry for IgG4. We encountered 3 such patients in a tertiary care hospital in India. Two patients presented with obstructive jaundice and the third with pain abdomen. They had resectable lesions involving the pancreatic head, the right hepatic duct, and gallbladder fundus, respectively, on imaging. Tumor markers were not significantly elevated in any of them. All 3 patients underwent radical surgeries, suspecting malignancy. Surgical specimens showed typical features of IgG4-RD on histomorphology. Serum IgG4 level was elevated in first 2 patients but was normal in sclerosing cholecystitis patient. To conclude, IgG4-RD is a malignant mimicker; hence, on clinical suspicion, liberal attempts for tissue diagnosis may avoid radical surgeries | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a autoimmune pancreatitis | |
650 | 4 | |a immunoglobulin G4 sclerosing cholangitis | |
650 | 4 | |a immunoglobulin G4-related cholecystitis | |
650 | 4 | |a immunoglobulin G4-related disease | |
650 | 4 | |a immunoglobulin G4-related pancreatocholangiopathy | |
650 | 7 | |a Immunoglobulin G |2 NLM | |
700 | 1 | |a Rakesh, Nirjhar Raj |e verfasserin |4 aut | |
700 | 1 | |a Kaushal, Gourav |e verfasserin |4 aut | |
700 | 1 | |a Ramachandra, Deepti |e verfasserin |4 aut | |
700 | 1 | |a Goyal, Anuj |e verfasserin |4 aut | |
700 | 1 | |a Karthyarth, Mithun Nariampalli |e verfasserin |4 aut | |
700 | 1 | |a Azad, Shweta |e verfasserin |4 aut | |
700 | 1 | |a Sanyal, Sumit |e verfasserin |4 aut | |
700 | 1 | |a Dhar, Puneet |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t The American surgeon |d 1951 |g 89(2023), 6 vom: 16. Juni, Seite 2985-2988 |w (DE-627)NLM000046418 |x 1555-9823 |7 nnns |
773 | 1 | 8 | |g volume:89 |g year:2023 |g number:6 |g day:16 |g month:06 |g pages:2985-2988 |
856 | 4 | 0 | |u http://dx.doi.org/10.1177/00031348221102610 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 89 |j 2023 |e 6 |b 16 |c 06 |h 2985-2988 |