Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis : A pilot randomized controlled trial
© The Author(s), 2022..
Background: Patients with MS have an altered gut microbiota compared to healthy individuals, as well as elevated small intestinal permeability, which may be contributing to the development and progression of the disease.
Objective: We sought to investigate if fecal microbiota transplantation was safe and tolerable in MS patients and if it could improve abnormal intestinal permeability.
Methods: Nine patients with MS were recruited and provided monthly FMTs for up to six months. The primary outcome investigated was change in peripheral blood cytokine concentrations. The secondary outcomes were gut microbiota composition, intestinal permeability, and safety (assessed with EDSS and MRI).
Results: The study was terminated early and was subsequently underpowered to assess whether peripheral blood cytokines were altered following FMTs. FMTs were safe in this group of patients. Two of five patients had elevated small intestinal permeability at baseline that improved to normal values following FMTs. Significant, donor-specific, beneficial alterations to the MS patient gut microbiota were observed following FMT.
Conclusion: FMT was safe and tolerable in this cohort of RRMS patients, may improve elevated small intestinal permeability, and has the potential to enrich for an MS-protective microbiota. Further studies with longer follow-up and larger sample sizes are required to determine if FMT is a suitable therapy for MS.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
|---|---|
| Enthalten in: |
Multiple sclerosis journal - experimental, translational and clinical - 8(2022), 2 vom: 05. Apr., Seite 20552173221086662 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Al, Kait F [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Fecal microbiota transplantation |
|---|
| Anmerkungen: |
Date Revised 16.07.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1177/20552173221086662 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM340948531 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM340948531 | ||
| 003 | DE-627 | ||
| 005 | 20231226010635.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/20552173221086662 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1136.xml |
| 035 | |a (DE-627)NLM340948531 | ||
| 035 | |a (NLM)35571974 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Al, Kait F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis |b A pilot randomized controlled trial |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 16.07.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s), 2022. | ||
| 520 | |a Background: Patients with MS have an altered gut microbiota compared to healthy individuals, as well as elevated small intestinal permeability, which may be contributing to the development and progression of the disease | ||
| 520 | |a Objective: We sought to investigate if fecal microbiota transplantation was safe and tolerable in MS patients and if it could improve abnormal intestinal permeability | ||
| 520 | |a Methods: Nine patients with MS were recruited and provided monthly FMTs for up to six months. The primary outcome investigated was change in peripheral blood cytokine concentrations. The secondary outcomes were gut microbiota composition, intestinal permeability, and safety (assessed with EDSS and MRI) | ||
| 520 | |a Results: The study was terminated early and was subsequently underpowered to assess whether peripheral blood cytokines were altered following FMTs. FMTs were safe in this group of patients. Two of five patients had elevated small intestinal permeability at baseline that improved to normal values following FMTs. Significant, donor-specific, beneficial alterations to the MS patient gut microbiota were observed following FMT | ||
| 520 | |a Conclusion: FMT was safe and tolerable in this cohort of RRMS patients, may improve elevated small intestinal permeability, and has the potential to enrich for an MS-protective microbiota. Further studies with longer follow-up and larger sample sizes are required to determine if FMT is a suitable therapy for MS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 4 | |a fecal microbiota transplantation | |
| 650 | 4 | |a intestinal permeability | |
| 650 | 4 | |a microbiome | |
| 700 | 1 | |a Craven, Laura J |e verfasserin |4 aut | |
| 700 | 1 | |a Gibbons, Shaeley |e verfasserin |4 aut | |
| 700 | 1 | |a Parvathy, Seema Nair |e verfasserin |4 aut | |
| 700 | 1 | |a Wing, Ana Christina |e verfasserin |4 aut | |
| 700 | 1 | |a Graf, Chantelle |e verfasserin |4 aut | |
| 700 | 1 | |a Parham, Kate A |e verfasserin |4 aut | |
| 700 | 1 | |a Kerfoot, Steven M |e verfasserin |4 aut | |
| 700 | 1 | |a Wilcox, Hannah |e verfasserin |4 aut | |
| 700 | 1 | |a Burton, Jeremy P |e verfasserin |4 aut | |
| 700 | 1 | |a Kremenchutzky, Marcelo |e verfasserin |4 aut | |
| 700 | 1 | |a Morrow, Sarah A |e verfasserin |4 aut | |
| 700 | 1 | |a Casserly, Courtney |e verfasserin |4 aut | |
| 700 | 1 | |a Meddings, Jon |e verfasserin |4 aut | |
| 700 | 1 | |a Sharma, Manas |e verfasserin |4 aut | |
| 700 | 1 | |a Silverman, Michael S |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Multiple sclerosis journal - experimental, translational and clinical |d 2015 |g 8(2022), 2 vom: 05. Apr., Seite 20552173221086662 |w (DE-627)NLM254462944 |x 2055-2173 |7 nnns |
| 773 | 1 | 8 | |g volume:8 |g year:2022 |g number:2 |g day:05 |g month:04 |g pages:20552173221086662 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1177/20552173221086662 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 8 |j 2022 |e 2 |b 05 |c 04 |h 20552173221086662 | ||