Biliary cancer brain metastases : a multi-institution case series with case reports
2022 Journal of Gastrointestinal Oncology. All rights reserved..
Background: Biliary cancers are rare, and few reported cases of brain metastases from primary biliary cancers exist, especially describing patients in the United States. This report assesses the proportion and incidence of brain metastases arising from primary biliary cancers [cholangiocarcinoma (CCA) and gallbladder cancer] at Stanford University and the University of California, San Francisco, describes clinical characteristics, and provides a case series.
Methods: We queried 3 clinical databases at Stanford and the University of California, San Francisco to retrospectively identify and review the charts of 15 patients with brain metastases from primary biliary cancers occurring between 1990 to 2020.
Results: Among patients with brain metastases analyzed at Stanford (3,585), 6 had a primary biliary cancer, representing 0.17% of all brain metastases. Among biliary cancer patients at the University of California, San Francisco (1,055), 9 had brain metastases, representing an incidence in biliary cancer of 0.85%. A total of 15 biliary cancer patients with brain metastases were identified at the two institutions. Thirteen out of 15 patients (86.7%, 95% CI: 59.5-98.3) were female. The median overall survival from primary biliary cancer diagnosis was 214 days (95% CI: 71.69-336.82 days) and subsequent OS from the time of brain metastasis diagnosis was 57 days (95% CI: 13.43-120.64 days). Death within 90 days of brain metastasis diagnosis occurred in 66.67% of patients (95% CI: 38.38-88.17).
Conclusions: Brain metastases from primary biliary cancers are rare, with limited survival once diagnosed. This report can aid health care providers in caring for patients with brain metastases from primary biliary cancers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Journal of gastrointestinal oncology - 13(2022), 2 vom: 25. Apr., Seite 822-832 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Falkson, Samuel R [VerfasserIn] |
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| Links: |
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| Themen: |
Biliary cancers |
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| Anmerkungen: |
Date Revised 02.08.2022 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.21037/jgo-21-818 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM340812303 |
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| 100 | 1 | |a Falkson, Samuel R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Biliary cancer brain metastases |b a multi-institution case series with case reports |
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| 500 | |a Date Revised 02.08.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a 2022 Journal of Gastrointestinal Oncology. All rights reserved. | ||
| 520 | |a Background: Biliary cancers are rare, and few reported cases of brain metastases from primary biliary cancers exist, especially describing patients in the United States. This report assesses the proportion and incidence of brain metastases arising from primary biliary cancers [cholangiocarcinoma (CCA) and gallbladder cancer] at Stanford University and the University of California, San Francisco, describes clinical characteristics, and provides a case series | ||
| 520 | |a Methods: We queried 3 clinical databases at Stanford and the University of California, San Francisco to retrospectively identify and review the charts of 15 patients with brain metastases from primary biliary cancers occurring between 1990 to 2020 | ||
| 520 | |a Results: Among patients with brain metastases analyzed at Stanford (3,585), 6 had a primary biliary cancer, representing 0.17% of all brain metastases. Among biliary cancer patients at the University of California, San Francisco (1,055), 9 had brain metastases, representing an incidence in biliary cancer of 0.85%. A total of 15 biliary cancer patients with brain metastases were identified at the two institutions. Thirteen out of 15 patients (86.7%, 95% CI: 59.5-98.3) were female. The median overall survival from primary biliary cancer diagnosis was 214 days (95% CI: 71.69-336.82 days) and subsequent OS from the time of brain metastasis diagnosis was 57 days (95% CI: 13.43-120.64 days). Death within 90 days of brain metastasis diagnosis occurred in 66.67% of patients (95% CI: 38.38-88.17) | ||
| 520 | |a Conclusions: Brain metastases from primary biliary cancers are rare, with limited survival once diagnosed. This report can aid health care providers in caring for patients with brain metastases from primary biliary cancers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Brain metastases | |
| 650 | 4 | |a biliary cancers | |
| 650 | 4 | |a cholangiocarcinoma (CCA) | |
| 650 | 4 | |a gallbladder adenocarcinoma (GBA) | |
| 650 | 4 | |a gallbladder cancer | |
| 700 | 1 | |a Zhang, Karen |e verfasserin |4 aut | |
| 700 | 1 | |a Bhambhvani, Hriday P |e verfasserin |4 aut | |
| 700 | 1 | |a Wild, Jennifer L |e verfasserin |4 aut | |
| 700 | 1 | |a Griffin, Ann |e verfasserin |4 aut | |
| 700 | 1 | |a Kelley, Robin K |e verfasserin |4 aut | |
| 700 | 1 | |a Gephart, Melanie Hayden |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:13 |g year:2022 |g number:2 |g day:25 |g month:04 |g pages:822-832 |
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