Assessment of bone health in patients with prostate cancer using cancer staging computed tomography
© 2022. The Japanese Society Bone and Mineral Research..
PURPOSE: To evaluate the utility of vertebral Hounsfield unit (HU) values from computed tomography (CT) in cancer staging as a supplementary screening tool for bone health among prostate cancer (PCa) patients.
METHODS: T-scores of bone mineral density (BMD) in each lumbar vertebra (L1-L4) and hip for newly diagnosed PCa patients (N = 139) were measured using dual-energy X-ray absorptiometry (DXA). The degenerative changes in each lumbar vertebra were assessed, and the HU values of trabecular bone in axial CT images of each vertebral body (vertebral CT-HU value) were measured using staging CT.
RESULTS: 556 vertebrae were analyzed. 326 of 556 (59%) lumbar vertebrae had degenerative changes. The vertebral CT-HU value was positively correlated with the lumbar BMD T-score, with higher correlation coefficients observed in vertebrae without degenerative changes (r = 0.655, N = 230) when compared to vertebrae with degenerative changes (r = 0.575, N = 326). The thresholds matching BMD T-scores of - 2.0 and - 1.5 set by cancer treatment-induced bone loss guidelines were 95 HU and 105 HU, respectively. Based on the intervention threshold (lumbar BMD T-score < - 1.5), 15.1% of PCa patients required osteoporosis treatment; and, this value increased to 30.9% when L1-L4 CT-HU thresholds that corresponded to BMD T-score < - 1.5 were used.
CONCLUSION: Lumbar BMD values from DXA may not reflect true bone health in PCa patients who often have lumbar degenerative diseases. Thresholds based on the vertebral CT-HU value can be used as a supplementary method to identify PCa patients who need anti-osteoporosis drugs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Journal of bone and mineral metabolism - 40(2022), 4 vom: 11. Juli, Seite 648-656 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sato, Mototaka [VerfasserIn] |
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| Links: |
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| Themen: |
Bone mineral density |
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| Anmerkungen: |
Date Completed 07.07.2022 Date Revised 14.07.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00774-022-01328-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM340745398 |
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| 100 | 1 | |a Sato, Mototaka |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Assessment of bone health in patients with prostate cancer using cancer staging computed tomography |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 14.07.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Japanese Society Bone and Mineral Research. | ||
| 520 | |a PURPOSE: To evaluate the utility of vertebral Hounsfield unit (HU) values from computed tomography (CT) in cancer staging as a supplementary screening tool for bone health among prostate cancer (PCa) patients | ||
| 520 | |a METHODS: T-scores of bone mineral density (BMD) in each lumbar vertebra (L1-L4) and hip for newly diagnosed PCa patients (N = 139) were measured using dual-energy X-ray absorptiometry (DXA). The degenerative changes in each lumbar vertebra were assessed, and the HU values of trabecular bone in axial CT images of each vertebral body (vertebral CT-HU value) were measured using staging CT | ||
| 520 | |a RESULTS: 556 vertebrae were analyzed. 326 of 556 (59%) lumbar vertebrae had degenerative changes. The vertebral CT-HU value was positively correlated with the lumbar BMD T-score, with higher correlation coefficients observed in vertebrae without degenerative changes (r = 0.655, N = 230) when compared to vertebrae with degenerative changes (r = 0.575, N = 326). The thresholds matching BMD T-scores of - 2.0 and - 1.5 set by cancer treatment-induced bone loss guidelines were 95 HU and 105 HU, respectively. Based on the intervention threshold (lumbar BMD T-score < - 1.5), 15.1% of PCa patients required osteoporosis treatment; and, this value increased to 30.9% when L1-L4 CT-HU thresholds that corresponded to BMD T-score < - 1.5 were used | ||
| 520 | |a CONCLUSION: Lumbar BMD values from DXA may not reflect true bone health in PCa patients who often have lumbar degenerative diseases. Thresholds based on the vertebral CT-HU value can be used as a supplementary method to identify PCa patients who need anti-osteoporosis drugs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bone mineral density | |
| 650 | 4 | |a CT Hounsfield unit value | |
| 650 | 4 | |a Dual-energy X-ray absorptiometry | |
| 650 | 4 | |a Lumbar degenerative disease | |
| 650 | 4 | |a Prostate cancer | |
| 700 | 1 | |a Kashii, Masafumi |e verfasserin |4 aut | |
| 700 | 1 | |a Matsukawa, Atsuki |e verfasserin |4 aut | |
| 700 | 1 | |a Mizuno, Ryoya |e verfasserin |4 aut | |
| 700 | 1 | |a Akiyama, Mai |e verfasserin |4 aut | |
| 700 | 1 | |a Kamatani, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Kamido, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Ueda, Norichika |e verfasserin |4 aut | |
| 700 | 1 | |a Nakayama, Jiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tei, Norihide |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshikawa, Hideki |e verfasserin |4 aut | |
| 700 | 1 | |a Miyake, Osamu |e verfasserin |4 aut | |
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