Diverse dihydroagarofuran sesquiterpene derivatives from the stem and branch of Tripterygium wilfordii
Copyright © 2022. Published by Elsevier B.V..
Ten new dihydroagarofuran sesquiterpene polyol esters, tripterdines A-J (1-10) were isolated from the stem and branch of Tripterygium wilfordii. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses, including UV, IR, HRESIMS, NMR, and CD exciton chirality method. The structures of compounds 1, 3, and 6 were confirmed by X-ray crystallographic analyses. The anti-inflammatory and cytotoxic activities were assessed for all the compounds (1-10). Compounds 3, 5 and 10 exhibited potent anti-inflammatory activities with the secretion level of TNF-α ranging from 43.86% to 51.27%, and the IL-6 ranging from 32.44% to 50.64%. In addition, compounds 1, 3, 7 and 9 showed weak cytotoxicities against three human tumor cell lines (Huh7, MCF-7 and HCT-116).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:160 |
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| Enthalten in: |
Fitoterapia - 160(2022) vom: 01. Juli, Seite 105205 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hu, Ya-Lin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 21.06.2022 Date Revised 21.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fitote.2022.105205 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Ten new dihydroagarofuran sesquiterpene polyol esters, tripterdines A-J (1-10) were isolated from the stem and branch of Tripterygium wilfordii. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses, including UV, IR, HRESIMS, NMR, and CD exciton chirality method. The structures of compounds 1, 3, and 6 were confirmed by X-ray crystallographic analyses. The anti-inflammatory and cytotoxic activities were assessed for all the compounds (1-10). Compounds 3, 5 and 10 exhibited potent anti-inflammatory activities with the secretion level of TNF-α ranging from 43.86% to 51.27%, and the IL-6 ranging from 32.44% to 50.64%. In addition, compounds 1, 3, 7 and 9 showed weak cytotoxicities against three human tumor cell lines (Huh7, MCF-7 and HCT-116) | ||
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| 650 | 4 | |a Ethanol (PubChem CID: 702) | |
| 650 | 4 | |a Methanol (PubChem CID: 887) | |
| 650 | 4 | |a Methyl cyanide (PubChem CID: 6432) | |
| 650 | 4 | |a Methylene chloride (PubChem CID: 6344) | |
| 650 | 4 | |a Sesquiterpenoid | |
| 650 | 4 | |a Tripterygium wilfordii | |
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| 700 | 1 | |a Zhang, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yu-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Guang-Xiong |e verfasserin |4 aut | |
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